Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: Review and meta-analysis
Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: Review and meta-analysis
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DOI：
10.1002/ijc.22851
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发表时间：
2007-10-15
影响因子：
6.4
通讯作者：
Taioli, Emanuela
中科院分区：
文献类型：
--
作者：
Ragin, Camille C. R.;Taioli, Emanuela
人乳头瘤病毒（HPV）与头颈部鳞状细胞癌（HNSCC）有关，特别是口咽部，在扁桃体中分布最高。HPV感染与预后改善有关，尽管并非所有研究都显示一致的结果。原因尚不清楚。我们回顾了所有发表的文章，并对HPV感染与HNSCC总生存期（0S）和无病生存期（DFS）之间的总体关系进行了荟萃分析。hpv阳性HNSCC患者的死亡风险（meta HR: 0.85, 95% Cl: 0.7-1.0）低于hpv阴性HNSCC患者，复发风险（meta HR: 0.62, 95% ci: 0.5-0.8）低于hpv阴性HNSCC患者。位点特异性分析显示，与hpv阴性口咽肿瘤患者相比，hpv阳性口咽肿瘤患者的死亡风险降低了28% （meta HR: 0.72, 95%CI: 0.5-1.0）。类似的观察结果也存在（meta HR: 0.51, 95% Cl: 0.4-0.7）。hpv阳性和阴性的非口咽部患者的0无差异。观察到的hpv阳性HNSCC患者OS和DFS的改善仅针对口咽部；这些肿瘤可能与那些在非口咽部位的肿瘤有不同的病因。(C) 2007 Wiley-Liss, Inc。
Human papillomavirus (HPV) has been associated with head and neck squamous cell carcinomas (HNSCC), especially of the oropharynx, with highest distribution in the tonsils. HPV infection has been associated With improved outcome, although not all the studies show consistent results. The reason for this is not clear. We reviewed all published articles and conducted a meta-analysis on the overall relationship between HPV infection and overall survival (0S) and disease-free survival (DFS) in HNSCC. Patients with HPV-positive HNSCC had a lower risk of dying (meta HR: 0.85, 95% Cl: 0.7-1.0), and a lower risk of recurrence (meta HR: 0.62, 95%CI: 0.5-0.8) than HPV-negative HNSCC patients. Site-specific analyses show that patients with HPV-positive oropharyngeal tumours had a 28% reduced risk of death (meta HR: 0.72, 95%CI: 0.5-1.0) in comparison to patients with HPV-negative oropharyngeal tumours. Similar observations were made or (meta HR: 0.51, 95% Cl: 0.4-0.7). There was no difference in 0 between HPV-positive and negative non-oropharyngeal patients. The observed improved OS and DFS for HPV-positive HNSCC patients is specific to the oropharynx; these tumours may have a distinct etiology from those tumours in non-oropharyngeal sites. (C) 2007 Wiley-Liss, Inc.