Advanced Glycation Endproducts and Bone Material Strength in Type 2 Diabetes
Advanced Glycation Endproducts and Bone Material Strength in Type 2 Diabetes
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DOI：
10.1210/jc.2016-1437
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发表时间：
2016-06-01
影响因子：
5.8
通讯作者：
Rubin, Mishaela R.
中科院分区：
文献类型：
--
作者：
Furst, Jessica R.;Bandeira, Leonardo C.;Rubin, Mishaela R.
背景：导致骨折风险增加的骨骼退化是2型糖尿病（T2 D）的一种已知并发症。目的：本研究的目的是确定T2 D患者的骨材料特性（通过参考点压痕测量）和晚期糖基化终产物（AGEs）（通过皮肤自体荧光（SAF）测定）是否相关。设计：这是一项横断面研究。设置：本研究在一家三级医疗中心进行。患者：16名绝经后T2 D妇女和19名匹配的对照者参加了本研究。主要结果测量：通过体内参考点压痕法测量骨材料强度指数（BMSi），通过SAF测量AGE累积，以及测量循环骨转换标志物。结果：T2 D患者的BMSi降低了9.2%（P = 0.02），与T2 D持续时间呈负相关（r =-0.68，P = 0.004）。在T2 D患者中，SAF增加与BMSi降低（r =-0.65，P = .006）和骨形成标志物1型前胶原氨基末端前肽降低（r =-0.63，P = .01）相关，而在对照组中未观察到相关性。SAF占26%的年龄调整后的方差BMSi在T2 D（P = 0.03）。结论：骨材料性能受损的绝经后妇女与T2 D确定参考点压痕。结果表明AGEs的积累在T2 D中占BMSi的劣势。
Context: Skeletal deterioration, leading to an increased risk of fracture, is a known complication of type 2 diabetes mellitus (T2D). Yet plausible mechanisms to account for skeletal fragility in T2D have not been clearly established.Objective: The objective of the study was to determine whether bone material properties, as measured by reference point indentation, and advanced glycation endproducts (AGEs), as determined by skin autofluorescence (SAF), are related in patients with T2D.Design: This was a cross-sectional study.Setting: The study was conducted at a tertiary medical center.Patients: Sixteen postmenopausal women with T2D and 19 matched controls participated in the study.Main Outcome Measures: Bone material strength index (BMSi) by in vivo reference point indentation, AGE accumulation by SAF, and circulating bone turnover markers were measured.Results: BMSi was reduced by 9.2% in T2D (P = .02) and was inversely associated with the duration of T2D (r = -0.68, P = .004). Increased SAF was associated with reduced BMSi (r = -0.65, P = .006) and lower bone formation marker procollagen type 1 amino-terminal propeptide (r = -0.63, P = .01) in T2D, whereas no associations were seen in controls. SAF accounted for 26% of the age-adjusted variance in BMSi in T2D (P = .03).Conclusions: Bone material properties are impaired in postmenopausal women with T2D as determined by reference point indentation. The results suggest a role for the accumulation of AGEs to account for inferior BMSi in T2D.