Induction of DNA damage by oxidised amino acids and proteins
Induction of DNA damage by oxidised amino acids and proteins
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DOI：
10.1023/a:1015228001561
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发表时间：
2002-01-01
期刊：
影响因子：
4.5
通讯作者：
Davies, MJ
中科院分区：
文献类型：
--
作者：
Luxford, C;Dean, RT;Davies, MJ
氨基酸、肽和蛋白质在O-2存在下暴露于自由基会以剂量依赖性方式产生氢过氧化物。这些氢过氧化物在不存在外源催化剂（例如热、光、氧化还原活性过渡金属离子）的情况下是稳定的，但在这些试剂的存在下迅速分解以产生各种自由基，包括烷氧基（RO），过氧化氢（ROO.）和碳中心（R-.）这些自由基被证明与DNA发生反应，产生DNA-蛋白质交联和单链断裂。
Exposure of amino acids, peptides and proteins to radicals in the presence of O-2 generates hydroperoxides in a dose-dependent manner. These hydroperoxides are stable in the absence of exogenous catalysts (e.g. heat, light, redox-active transition metal ions), but decompose rapidly in the presence of these agents to give a variety of radicals including alkoxyl (RO.), peroxyl (ROO.) and carbon-centred (R-.) species, These radicals are shown to react with DNA to give DNA-protein cross-links and single strand breaks.