Selective toxin sequestrants for the treatment of bacterial infections.
Selective toxin sequestrants for the treatment of bacterial infections.
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选择性毒素螯合剂用于治疗细菌感染。
DOI：
10.1021/ja900852k
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发表时间：
2009-04-29
影响因子：
15
通讯作者：
Kodadek T
中科院分区：
文献类型：
--
作者：
Simpson LS;Burdine L;Dutta AK;Feranchak AP;Kodadek T
Bacterial toxin-mediated diarrheal disease is a major cause of morbidity and mortality worldwide. In this work we designed an on-bead library of protease-resistant, acid-stable peptoid molecules and screened for high affinity binding of cholera toxin. From 100,000 compounds, we discovered a single sequence of residues that can bind and retain cholera toxin at high affinity when immobilized on a solid-phase particle. Furthermore, we demonstrate that these peptoid-displaying particles can sequester active cholera toxin from cell culture media sufficient to protect intestinal cells. We foresee this work as contributory to a potential adjunct therapeutic strategy against cholera infections and other toxin-mediated diseases.
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影响因子：
168.9
作者：
Lopez, Alan D.;Mathers, Colin D.;Murray, Christopher J. L.
通讯作者：
Murray, Christopher J. L.
DOI：
10.1073/pnas.89.20.9367
发表时间：
1992-10-15
影响因子：
11.1
作者：
SIMON, RJ;KANIA, RS;BARTLETT, PA
通讯作者：
BARTLETT, PA
DOI：
10.1152/ajpgi.1997.273.5.g1108
发表时间：
1997-11-01
影响因子：
4.5
作者：
Schlenker, T;Romac, JMJ;Fitz, JG
通讯作者：
Fitz, JG
影响因子：
158.5
作者：
Saha, Debasish;Karim, Mohammad M.;Bennish, Michael L.
通讯作者：
Bennish, Michael L.
影响因子：
64.8
作者：
Kitov, PI;Sadowska, JM;Bundle, DR
通讯作者：
Bundle, DR