Association between Exposure to Endocrine Disruptors in Drinking Water and Preterm Birth, Taking Neighborhood Deprivation into Account: A Historic Cohort Study.
Association between Exposure to Endocrine Disruptors in Drinking Water and Preterm Birth, Taking Neighborhood Deprivation into Account: A Historic Cohort Study.
复制标题
DOI：
10.3390/ijerph13080796
复制
发表时间：
2016-08-09
影响因子：
--
通讯作者：
Migeot V
中科院分区：
文献类型：
--
作者：
Albouy-Llaty M;Limousi F;Carles C;Dupuis A;Rabouan S;Migeot V
背景：饮用水中的内分泌干扰物暴露与早产之间的关系只是偶尔才被研究。本研究的目的是研究孕期饮用水中阿特拉津代谢物或阿特拉津/硝酸盐混合物的暴露与新生儿肺结核患病率的关系，同时考虑到邻里关系的剥夺。方法：对2005年至2010年在法国德克斯-S进行的一项历史队列研究，使用阿特拉津代谢物暴露资料的多重归因模型和Logistic回归分析。结果：我们纳入了居住在279个不同人口普查地区的13654对母亲/新生儿。肺结核患病率为4%。平均阿特拉津代谢物浓度为0.019±0.009(0.014-0.080)微克/L，39%的母亲生活在较贫困地区。个体资料与肺结核发病风险相关。经混杂因素调整后，暴露于最高浓度的阿特拉津代谢物时患肺结核的风险为ORA 1.625，95%CI[0.975；2.710]。不管是否考虑到邻里关系的剥夺，结果都没有改变。暴露在阿特拉津/硝酸盐混合物中的情况仍然不明显。结论：即使我们考虑到邻里关系的剥夺，我们也不能证明怀孕中期饮用水中的阿特拉津代谢物或混合物与肺结核之间存在显著的关系。
Background: The relationship between preterm birth (PTB) and endocrine disruptor exposure in drinking-water has only occasionally been studied. The objective of this work was to investigate the relation between exposure to atrazine metabolites, or atrazine/nitrate mixtures, in drinking-water during pregnancy and prevalence of PTB neonates, while taking neighborhood deprivation into account. Method: A historic cohort study in Deux-Sèvres, France, between 2005 and 2010 with a multiple imputation model for data of exposure to atrazine metabolites and a logistic regression were carried out. Results: We included 13,654 mother/neonate pairs living in 279 different census districts. The prevalence of PTB was 4%. Average atrazine metabolite concentration was 0.019 ± 0.009 (0.014–0.080) µg/L and 39% of mothers lived in less deprived areas. The individual data were associated with risk of PTB. The risk of PTB when exposed to highest concentration of atrazine metabolite adjusted for confounders, was ORa 1.625 95% CI [0.975; 2.710]. Taking, or not, neighborhood deprivation into account did not change the result. Exposure to atrazine/nitrate mixtures remained non-significant. Conclusions: Even if we took neighborhood deprivation into account, we could not show a significant relationship between exposure to atrazine metabolites, or mixtures, in drinking-water during the second trimester of pregnancy and PTB.