Effect of body mass index on insulin secretion or sensitivity and diabetes.
Effect of body mass index on insulin secretion or sensitivity and diabetes.
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DOI：
10.1016/j.amepre.2014.09.009
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发表时间：
2015-02
影响因子：
5.5
通讯作者：
Y. Tatsumi;A. Morimoto;N. Miyamatsu;Mitsuhiko Noda;Y. Ohno;K. Deura
中科院分区：
文献类型：
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作者：
Y. Tatsumi;A. Morimoto;N. Miyamatsu;Mitsuhiko Noda;Y. Ohno;K. Deura
背景虽然肥胖和糖尿病之间的联系是众所周知的，但非肥胖亚洲人糖尿病的易感因素还不太清楚。目的在佐久研究中，根据BMI调查胰岛素分泌受损（IIS）和胰岛素抵抗（IR）对糖尿病发病率的影响。083名年龄在30-69岁之间的基线无糖尿病的参与者（2006-2007年）。参与者按BMI（<23.0，23.0-24.9和≥25）分层。根据胰岛素生成指数和IR值的稳态模型，将受试者分为四类：正常、单纯IIS（i-IIS）、单纯IR（i-IR）、所有数据收集于2006-2011年，并于2013- 2014年进行分析。结果对于BMI <23. 0的受试者，i-IIS组发生糖尿病的风险较高（校正后的危险比=6.6; 95%CI =3.7，11.6）和IIS + IR组（9.4; 3.1，28.4）均高于正常组。对于BMI为23.0-24.9的受试者，i-IIS（9.9; 4.4，22.1）; i-IR（3.4; 1.2，9.5）和IIS + IR（23.4; 9.3，58.9）组的风险较高。在BMI ≥25的受试者中，i-IIS组（16.9; 6.0，47.7）、i-IR组（7.9; 2.8，22.6）和IIS + IR组（26.9; 9.0，80.8）的风险较高。BMI与IIS的发病率呈负相关，但与IR incidence.ConclusionsIndividuals可能发展糖尿病主要通过IIS，而高BMI的人可能发展糖尿病主要通过IR。
BackgroundAlthough the association between obesity and diabetes is well known, the factors predisposing to diabetes in non-obese Asians are less clearly characterized.PurposeTo investigate the effects of impaired insulin secretion (IIS) and insulin resistance (IR) according to BMI on the incidence of diabetes in the Saku Study.MethodsThis 4-year cohort study involved 3,083 participants aged 30–69 years without diabetes at baseline (2006–2007). Participants were stratified by BMI (<23.0, 23.0–24.9, and ≥25). Based on insulinogenic index and homeostasis model of IR values, participants were classified into four categories: normal; isolated IIS (i-IIS); isolated IR (i-IR); and IIS plus IR. All data were collected in 2006–2011 and analyzed in 2013–2014.ResultsFor participants with BMI <23.0, the risk of developing diabetes was higher in the i-IIS (adjusted hazard ratio=6.6; 95% CI=3.7, 11.6) and IIS plus IR groups (9.4; 3.1, 28.4) than in the normal group. For participants with BMI 23.0–24.9, risk was higher in the i-IIS (9.9; 4.4, 22.1); i-IR (3.4; 1.2, 9.5); and IIS plus IR (23.4; 9.3, 58.9) groups. Among participants with BMI ≥25, risk was higher in the i-IIS (16.9; 6.0, 47.7); i-IR (7.9; 2.8, 22.6); and IIS plus IR (26.9; 9.0, 80.8) groups. BMI was negatively associated with incidence of IIS but positively associated with IR incidence.ConclusionsIndividuals with normal BMI may develop diabetes mainly through IIS, whereas individuals with high BMI may develop diabetes primarily through IR.