Hijacking the Bacterial Circuitry of Biofilm Processes via Chemical “Hot-Wiring”: An Under-explored Avenue for Therapeutic Development
Hijacking the Bacterial Circuitry of Biofilm Processes via Chemical “Hot-Wiring”: An Under-explored Avenue for Therapeutic Development
复制标题
通过化学“热接线”劫持生物膜过程的细菌回路：一条尚未探索的治疗开发途径
DOI：
10.1021/acsinfecdis.9b00104
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发表时间：
2019
影响因子：
5.3
通讯作者：
Wuest, William M.
中科院分区：
文献类型：
--
作者：
Wilt, Ingrid K.;Hari, Taylor P.;Wuest, William M.
生物膜相关感染与慢性和复发性疾病有关。这些感染通常对当前的抗生素治疗不敏感，因为保护性细胞外基质和休眠或“持久”细胞的亚群。靶向参与生物膜形成的细菌回路，包括双组分系统、群体感应、多糖结构完整性和环核苷酸信号通路，有可能扩大现有的治疗药物库，从而催化抗生素开发的第二个黄金时代。
Biofilm-associated infections are linked to chronic and recurring illnesses. These infections are often not susceptible to current antibiotic treatments because of the protective exocellular matrix and subpopulations of dormant or “persister” cells. Targeting bacterial circuitry involved in biofilm formation, including two-component systems, quorum sensing, polysaccharide structural integrity, and cyclic nucleotide signaling pathways, has the potential to expand the existing arsenal of therapeutics, thus catalyzing a second golden age of antibiotic development.