Swallowing induces sequential activation of esophageal longitudinal smooth muscle.
Swallowing induces sequential activation of esophageal longitudinal smooth muscle.
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吞咽引起食管纵向平滑肌的连续激活。
DOI：
10.1152/ajpgi.1984.247.5.g515
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Goyal,RK
中科院分区：
文献类型：
--
作者：
Sugarbaker,DJ;Rattan,S;Goyal,RK
我们在麻醉负鼠的吞咽或迷走神经刺激引起的蠕动过程中，在肌纤维轴上施加微型应变计，检查了食管纵向和环行肌在三个不同水平（下食管括约肌上方 9、5 和 1 厘米）的机械活动。纵向肌肉收缩的开始发生在吞咽过程中，但与迷走神经刺激同时发生。吞咽时纵向肌肉激活的速度为 7.6 +/- 1.7 cm/s。在迷走神经刺激和吞咽速度分别为 4.1 +/- 0.8 和 2.3 +/- 0.1 cm/s 的情况下，循环肌肉收缩发生在 aboral 序列中。所有部位的纵向肌均先于环状肌收缩。随着吞咽或迷走神经刺激，纵向肌肉收缩的持续时间向外侧增加（P小于0.05）。这些研究表明：1）吞咽过程中，食管纵向和环形平滑肌以顺序方式收缩，2）纵向肌肉顺序收缩是由中枢机制引起的，而环形肌肉顺序收缩可能是由中枢和外周机制引起的，3）外周神经肌肉机制在纵向肌肉收缩的持续时间上产生区域差异。
We examined the mechanical activity of the longitudinal and circular muscles of the esophagus at three different levels (9, 5, and 1 cm above the lower esophageal sphincter) during peristalsis induced by swallows or vagal stimulation in anesthetized opossums with miniature strain gauges applied in the axis of muscle fibers. The onset of longitudinal muscle contraction occurred in an aboral sequence with swallows but simultaneously with vagal stimulation. The speed of longitudinal muscle activation with swallows was 7.6 +/- 1.7 cm/s. Circular muscle contraction occurred in an aboral sequence with vagal stimulation and swallowing with speeds of 4.1 +/- 0.8 and 2.3 +/- 0.1 cm/s, respectively. Longitudinal muscle contracted before the circular muscle at all sites. The duration of longitudinal muscle contraction increased aborally (P less than 0.05) with swallowing or vagal stimulation. These studies show that 1) during swallowing, esophageal longitudinal and circular smooth muscle contract in a sequential fashion, 2) the longitudinal muscle sequential contraction is due to central mechanisms, whereas circular muscle sequential contraction may be due to both central and peripheral mechanisms, and 3) peripheral neuromuscular mechanisms produce regional differences in the duration of longitudinal muscle contraction.