Single molecule SERS and detection of biomolecules with a single gold nanoparticle on a mirror junction
Single molecule SERS and detection of biomolecules with a single gold nanoparticle on a mirror junction
复制标题
DOI：
10.1039/c3an00447c
复制
发表时间：
2013-01-01
期刊：
影响因子：
4.2
通讯作者：
Mahajan, Sumeet
中科院分区：
文献类型：
--
作者：
Li, Li;Hutter, Tanya;Mahajan, Sumeet
使用双分析物的方法，我们明确地表明，一个单一的金纳米球上的金属膜结，在所谓的纳米粒子上的镜面配置，是能够单分子检测与表面增强拉曼光谱（Sers）。此外，这种配置作为一个方便的和高灵敏度的Sers传感器检测的生物分子。这种简单的基于纳米结的系统是化学和生物医学分析的理想选择。
Using the bianalyte method we unambiguously demonstrate that a single gold nanosphere on a metal film junction, in the so-called nanoparticle on a mirror configuration, is capable of single molecule detection with surface-enhanced Raman spectroscopy (SERS). Also this configuration serves as a convenient and highly sensitive SERS sensor for detection of biomolecules. Such simple nano-junction based systems are ideal for chemical and biomedical analysis.