CD25 regulatory T cells determine secondary but not primary remission in EAE:: Impact on long-term disease progression
CD25 regulatory T cells determine secondary but not primary remission in EAE:: Impact on long-term disease progression
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DOI：
10.1016/j.jneuroim.2005.11.003
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发表时间：
2006-03-01
影响因子：
3.3
通讯作者：
Brunner-Weinzierl, MC
中科院分区：
文献类型：
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作者：
Gärtner, D;Hoff, H;Brunner-Weinzierl, MC
多发性硬化症（MS）的特征通常是在长期疾病期间多次复发和缓解，但迄今为止既不知道负责细胞也不知道机制。使用多发性硬化症动物模型，在中枢神经系统中鉴定了复发性实验性自身免疫性脑脊髓炎（R-EAE）CD 4（+）CD 25（+）细胞内表达Foxp 3和CTLA-4的T-reg细胞以及表达表面CTLA-4的T淋巴细胞。即使在耗尽T-reg细胞后也发生了第一次缓解，但EAE的继发性缓解被消融。尽管第一次缓解未发生变化，但自身抗原再激发显示急性期细胞因子反应已经放大。这些结果表明，MS首次发作期间的细胞组成可预测长期疾病进展。(C)2005 Elsevier B. V.保留所有权利。
Multiple sclerosis (MS) is often characterized by several relapses and remissions during long-term disease, but neither the responsible cells nor the mechanisms are known to date. Using an animal model of multiple sclerosis, relapsing experimental autoimmune encephalomyelitis (R-EAE) CD4(+)CD25(+) T-reg Cells expressing Foxp3 and CTLA-4 intracellularly and T lymphocytes expressing surface CTLA-4 were identified in the CNS. The first remission occurred even after depletion of T-reg cells, but secondary remissions from EAE were ablated. Despite the unaltered first remission autoantigen rechallenge revealed already an amplified cytokine response during acute phase. These results indicate that the cellular composition during first attack of MS predicts long-term disease progression. (C) 2005 Elsevier B.V. All rights reserved.