Differential inhibitory effect of isoproterenol on contractions of canine airways.
Differential inhibitory effect of isoproterenol on contractions of canine airways.
复制标题
异丙肾上腺素对犬气道收缩的差异抑制作用。
DOI：
10.1152/jappl.1984.57.3.801
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Russell,JA
中科院分区：
文献类型：
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作者：
Russell,JA
我们研究了异丙肾上腺素对组胺、5-羟色胺（5-HT）和乙酰胆碱引起的离体犬气道收缩的抑制作用。通过使用激动剂浓度来匹配气道收缩，所述激动剂浓度产生先前暴露于10（-4）M乙酰胆碱期间产生的收缩力的约60%。引起组胺、5-HT和乙酰胆碱引起的收缩50%舒张的异丙肾上腺素浓度分别为9.9 × 10 ~（-9）、3.6 × 10 ~（-8）和9.0 × 10 ~（-8）M。组胺和5-羟色胺诱导的收缩分别在10（-7）和10（-6）M异丙肾上腺素时完全松弛，而异丙肾上腺素浓度大于或等于10（-4）M时，乙酰胆碱引起的气道收缩从未完全松弛。我们的结论是，异丙肾上腺素抑制组胺和5-羟色胺诱导的气道收缩比乙酰胆碱诱导的更有效。
We examined the inhibitory effect of isoproterenol on contractions of isolated canine airways induced by histamine, 5-hydroxytryptamine (5-HT), and acetylcholine. Airway contractions were matched by using agonist concentrations that produced approximately 60% of the contractile force generated during a previous exposure to 10(-4) M acetylcholine. Concentrations of isoproterenol causing 50% relaxations of histamine-, 5-HT-, and acetylcholine-induced contractions were 9.9 X 10(-9), 3.6 X 10(-8), and 9.0 X 10(-8) M, respectively. Total relaxation of histamine- and 5-HT-induced contractions occurred at 10(-7) and 10(-6) M isoproterenol, respectively, whereas isoproterenol concentrations greater than or equal to 10(-4) M never totally relaxed airways contracted by acetylcholine. We conclude that isoproterenol inhibits airway contractions induced by histamine and 5-HT much more effectively than those induced by acetylcholine.