Association of increased ligand cyclophilin A and receptor CD147 with hypoxia, angiogenesis, metastasis and prognosis of tongue squamous cell carcinoma
Association of increased ligand cyclophilin A and receptor CD147 with hypoxia, angiogenesis, metastasis and prognosis of tongue squamous cell carcinoma
复制标题
配体亲环蛋白A和受体CD147增加与舌鳞状细胞癌缺氧、血管生成、转移和预后的关系
DOI：
10.1111/j.1365-2559.2011.04130.x
复制
发表时间：
2012-04-01
期刊：
影响因子：
6.4
通讯作者：
Zhang, Wenfeng
中科院分区：
文献类型：
--
作者：
Huang, Congfa;Sun, Zhijun;Zhang, Wenfeng
目的：我们评估了配体亲环素A（CypA）和受体CD 147与舌鳞状细胞癌（TSCC）患者缺氧、血管生成、淋巴结转移和预后的关系。我们研究了CypA、CD 147、缺氧诱导因子1 α在正常肺组织中的表达，应用免疫组化法检测80例TSCC组织中HIF-1 α、VEGF-A和VEGF-C蛋白表达。CypA、CD 147、HIF-1 α、VEGF-A和VEGF-C在TSCC中的表达均高于正常口腔黏膜组织（P < 0.01）。配体CypA和受体CD 147的增加与HIF 1 α、VEGF-A和VEGF-C的表达显著相关。VEGF-A和VEGF-C在胃癌中的表达也有显著相关性（P < 0.01）。Kaplan-Meier分析显示，CypA、CD 147、HIF-1a和VEGF-C过表达的患者总生存期显著低于正常对照组（P < 0.05）。多因素考克斯回归分析显示，HIF-1 a、复发和远处转移是影响TSCC患者总生存率的独立预后因素。结论：配体CypA和受体CD 147的表达与TSCC的发生、缺氧、血管生成、转移和预后有关，提示配体CypA和受体CD 147可能对TSCC的预后有重要价值，并可作为潜在的治疗靶点。
Aims: We evaluated the association of ligand cyclophilin A (CypA) and receptor CD147 with hypoxia, angiogenesis, lymph node metastasis and prognosis of patients with tongue squamous cell carcinoma (TSCC).Methods and results: We studied the expression of CypA, CD147, hypoxia-inducible factor 1 alpha (HIF-1 alpha), vascular endothelial growth factor A and C (VEGF-A and VEGF-C) protein by immunohistochemistry in 80 specimens of TSCC. CypA, CD147, HIF-1 alpha, VEGF-A and VEGF-C were overexpressed in TSCCs, and were significantly higher than those in normal oral mucosa tissues (P < 0.01). Increased ligand CypA and receptor CD147 correlated significantly with expression of HIF1 alpha, VEGF-A and VEGF-C. A significant relationship between VEGF-A and VEGF-C was also detected (P < 0.01). Patients with overexpression of CypA, CD147, HIF-1a and VEGF-C had significantly worse overall survival (P < 0.05) using Kaplan-Meier analysis. Multivariate Cox regression analysis showed that HIF-1a, recurrence and distant metastasis were independent prognostic factors on overall survival in TSCC patients.Conclusions: The association of expression of ligand CypA and receptor CD147 with carcinogenesis, hypoxia, angiogenesis, metastasis and prognosis of TSCC suggests that ligand CypA and receptor CD147 may have prognostic value and could be regarded as potential therapeutic targets in TSCC.