Iron-catalyzed oxidative biaryl cross-couplings via mixed diaryl titanates: significant influence of the order of combining aryl Grignard reagents with titanate
Iron-catalyzed oxidative biaryl cross-couplings via mixed diaryl titanates: significant influence of the order of combining aryl Grignard reagents with titanate
复制标题
通过混合钛酸二芳基酯的铁催化氧化联芳基交叉偶联：芳基格氏试剂与钛酸酯结合顺序的显着影响
DOI：
10.1039/c5cc00514k
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发表时间：
2015
影响因子：
4.9
通讯作者：
Duan Xin Fang
中科院分区：
文献类型：
--
作者：
Liu Kun Ming;Wei Juan;Duan Xin Fang
混合钛酸二芳基酯首次用于修饰两种芳基格氏试剂的反应活性。通过交替格氏试剂与 ClTi(OR)3 组合的顺序形成的两种钛酸酯中间体 Ar[Ar'Ti(OR)3]MgX 和 Ar'[ArTi(OR)3]MgX 显示出显着的反应性差异。利用这种不同的反应性，两个结构高度相似的芳基可以通过铁催化的氧化交叉偶联（使用氧作为氧化剂）轻松组装。
The mixed diaryl titanates were used for the first time to modify the reactivity of two aryl Grignard reagents. Two titanate intermediates, Ar[Ar′Ti(OR)3]MgX and Ar′[ArTi(OR)3]MgX, formed via alternating the sequence of combining Grignard reagents with ClTi(OR)3 showed a significant reactivity difference. Taking advantage of such different reactivity, two highly structurally similar aryl groups could be facilely assembled through iron-catalyzed oxidative cross-couplings using oxygen as the oxidant.