Comparison of a Stool Antigen Test and Serology for the Diagnosis of Helicobacter pylori Infection in Mass Survey
Comparison of a Stool Antigen Test and Serology for the Diagnosis of Helicobacter pylori Infection in Mass Survey
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DOI：
10.1111/j.1523-5378.2009.00672.x
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发表时间：
2009-04-01
期刊：
影响因子：
4.4
通讯作者：
Fukuda, Shinsaku
中科院分区：
文献类型：
--
作者：
Shimoyama, Tadashi;Oyama, Takao;Fukuda, Shinsaku
在胃癌普查中，沿着检测血清幽门螺杆菌抗体和血清胃蛋白酶原（PG）Ⅰ、Ⅱ水平。最近，粪便抗原检测已发展成为一种新的非侵入性检测。我们检查了H。方法：对2005年4月接受普查的994名健康成年人进行血清学和粪便抗原检测，比较两种检测方法的检测结果，评价粪便抗原检测在人群中的适用性。男379例，女615例，平均年龄57.7岁。粪便样本用于测量H。幽门特异性抗原的酶免疫测定。检测血清H. pylori感染，并测定PGs I和II的水平以确定萎缩性胃炎的存在。pylori血清学和粪便抗原检测阳性率分别为61.4%和56.4%。两种检测方法的一致性不受试者性别和年龄的影响，但在萎缩性胃炎受试者中存在差异。特别是在303例严重萎缩性胃炎患者中，粪便抗原试验的阳性率（81.8%）明显低于血清学的阳性率（88.7%，p <0.05）。pylori感染，可用于诊断H.大规模调查中的幽门螺杆菌感染。应检查粪便抗原检测筛查胃癌的有效性。
Serum antibody to Helicobacter pylori is tested in mass screening for gastric cancer along with the level of serum pepsinogens (PG) I and II. Recently, stool antigen tests have been developed as a new non-invasive test. We examined H. pylori infection by both serology and stool antigen test in a mass survey and compared the results to estimate applicability of stool antigen test for mass survey.A total of 994 healthy adults who received mass survey in April 2005 were tested. There were 379 men and 615 women, and the mean age was 57.7 years old. Stool samples were used to measure a H. pylori-specific antigen by enzyme immunoassay. Serum samples were tested for the prevalence of IgG antibody to H. pylori, and the level of PGs I and II was also measured to determine the presence of atrophic gastritis.Infection of H. pylori was defined as positive 61.4% and 56.4% by serology and stool antigen test, respectively. The concordance of both tests was not affected by gender and age of the subjects but difference was seen in subjects with atrophic gastritis. In particular, positivity of stool antigen test (81.8%) was significantly lower than that of serology (88.7%, p < .05) in 303 subjects with severe atrophic gastritis.Stool antigen test, which detects present but not previous infection of H. pylori, would be applicable to diagnose H. pylori infection in mass survey. Usefulness of stool antigen tests for the screening of gastric cancer should be examined.