Food intake in Prader-Willi syndrome and controls with obesity after administration of a benzodiazepine receptor agonist
Food intake in Prader-Willi syndrome and controls with obesity after administration of a benzodiazepine receptor agonist
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DOI：
10.1002/j.1550-8528.1998.tb00311.x
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发表时间：
1998-01-01
期刊：
影响因子：
--
通讯作者：
Berntson, GG
中科院分区：
文献类型：
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作者：
Fieldstone, A;Zipf, WB;Berntson, GG
苯二氮卓受体（BZR）激动剂因其抗焦虑作用而被广泛应用，但其对哺乳动物摄食量的影响尚不清楚。本研究采用60分钟自由进食标准化试验，观察了BZR激动剂利血平急性给药后的摄食量受试者是12名患有Prader-Willi综合征（PWS）的个体，PWS是一种以极度暴食和病态肥胖为特征的疾病，11名肥胖对照者，PWS受试者显示出与食欲障碍相关的特征性暴食，消耗超过6：三明治的数量是肥胖症对照组的两倍，结果显示任一剂量的CDP对任一组的食物摄入量均无显著影响。血清测定显示获得了剂量依赖性的临床有效水平的CDP和活性代谢物，这些结果表明，在所使用的治疗水平下，BZR激动剂CDP的急性给药可能不会增加肥胖人群的食物摄入量，然而，CDP对人类人群食欲的慢性影响仍需要探索。
Benzodiazepine receptor (BZR) agonists, used extensively for their anxiolytic effects, have been shown to increase food intake in many mammalian species, Little information, however, is available on the effects of BZR agonists on feeding behaviors of humans, Food intake was evaluated in a 60-minute free-feeding standardized test after the acute administration of the BZR agonist chlordiazepoxide (CDP, Librium; 5 mg or 20 mg) or placebo, Subjects were 12 individuals with the Prader-Willi syndrome (PWS), a disorder characterized by extreme hyperphagia and morbid obesity, and 11 controls with obesity, PWS subjects showed the characteristic hyperghagia associated with the appetite disorder, consuming more than six: times as many sandwiches as controls with obesity, Results revealed no significant effect of either dose of CDP on the food intake of either group, Serum assays revealed that dose-dependent, clinically effective levels of CDP and active metabolites were achieved, These results suggest that acute administration of the BZR agonist CDP, at the therapeutic levels used, may not increase food intake in populations with obesity, However, the chronic effects of CDP on appetite in human populations still need to be explored.