Aggregation induced emission-based fluorescent nanoparticles: fabrication methodologies and biomedical applications
Aggregation induced emission-based fluorescent nanoparticles: fabrication methodologies and biomedical applications
复制标题
基于聚集诱导发射的荧光纳米粒子：制造方法和生物医学应用
DOI：
10.1039/c4tb00291a
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发表时间：
2014
影响因子：
7
通讯作者：
Wei Yen
中科院分区：
文献类型：
--
作者：
Zhang Xiqi;Zhang Xiaoyong;Tao Lei;Chi Zhenguo;Xu Jiarui;Wei Yen
新型荧光纳米粒子（FNP）生物探针具有比传统的小分子有机染料和荧光蛋白等分子探针更高的上级亮度和光稳定性，有望在生物医学和生物学领域产生新的医学诊断技术。潜在的有趣的纳米平台，用于各种生物医学应用是非常有吸引力的，由于潜在的，以避免暴露于有毒药物的人体组织，增强疏水治疗剂的输送和制造多功能成像，靶向和输送系统。本文综述了近年来（2007-2013年）基于聚集诱导发射（AIE）的新型荧光纳米粒子的研究进展，重点讨论了非共价和共价两种荧光体系的制备方法，并对AIE荧光纳米粒子的生物医学应用进行了总结。
Novel fluorescent nanoparticle (FNP)-based bioprobes are expected to generate new medical diagnostic techniques in biomedical and biological areas for their superior brightness and photostability compared with conventional molecular probes including small organic dyes and fluorescent proteins. Potentially interesting nanoscale platforms for various biomedical applications are greatly attractive due to the potential to avoid exposure of human tissues to toxic drugs, enhancing delivery of hydrophobic therapeutics and fabricating multifunctional imaging, targeting and delivery system. In this review, recent progress in the area of novel aggregation induced emission (AIE)-based FNPs is summarized over the past few years (2007–2013), and the reported fabrication methodologies of these fluorescent systems including non-covalent and covalent strategies are mainly discussed, and the biomedical applications of AIE-based FNPs are also summarized.