DISCLOSURE OF TRAUMA AND IMMUNE-RESPONSE TO A HEPATITIS-B VACCINATION PROGRAM
DISCLOSURE OF TRAUMA AND IMMUNE-RESPONSE TO A HEPATITIS-B VACCINATION PROGRAM
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DOI：
10.1037/0022-006x.63.5.787
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发表时间：
1995-10-01
影响因子：
5.9
通讯作者：
THOMAS, MG
中科院分区：
文献类型：
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作者：
PETRIE, KJ;BOOTH, RJ;THOMAS, MG
这项研究调查了创伤经历的情绪表达是否影响了对乙肝疫苗接种计划的免疫反应。40名乙肝抗体检测为阴性的医学生被随机分配到连续四次的每日会议中，撰写关于个人创伤事件或对照话题的文章。在完成写作的第二天，参与者接受了他们的第一次乙肝疫苗接种，在写作后1个月和4个月分别进行了强化注射。在每次接种前和6个月的随访中采集血液。与对照组相比，情感表达组的参与者在4个月和B个月的随访期显示出显著更高的乙肝抗体水平。在写完文章后立即发现的其他免疫变化是治疗组循环中辅助T淋巴细胞和嗜碱性粒细胞的数量显著减少。写作干预会影响免疫反应，这一发现进一步支持了情绪披露与健康之间的联系。
This study investigated whether emotional expression of traumatic experiences influenced the immune response to a hepatitis B vaccination program. Forty medical students who tested negative for hepatitis B antibodies were randomly assigned to write about personal traumatic events or control topics during 4 consecutive daily sessions. The day after completion of the writing, participants were given their first hepatitis B vaccination, with booster injections at 1 and 4 months after the writing. Blood was collected before each vaccination and at a 6-month follow-up. Compared with the control group, participants in the emotional expression group showed significantly higher antibody levels against hepatitis B at the 4 and B-month follow-up periods. Other immune changes evident immediately after writing were significantly lower numbers of circulating T helper lymphocytes and basophils in the treatment group. The finding that a writing intervention influences immune response provides further support for a link between emotional disclosure and health.