Role of hyaluronan synthase 2 to promote CD44‐dependent oral cavity squamous cell carcinoma progression
Role of hyaluronan synthase 2 to promote CD44‐dependent oral cavity squamous cell carcinoma progression
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DOI：
10.1002/hed.22991
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发表时间：
2013-04
期刊：
影响因子：
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通讯作者：
Steven J. Wang;Christine Earle;G. Wong;L. Bourguignon
中科院分区：
文献类型：
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作者：
Steven J. Wang;Christine Earle;G. Wong;L. Bourguignon
CD44是一种跨膜受体，存在于许多不同的良性和恶性细胞上。透明质酸(HA)是CD44受体的主要配体，是细胞外基质的主要成分。在癌细胞中，HA与CD44的相互作用促进了多条信号通路，这些信号通路影响了多种实体瘤中肿瘤细胞的进展行为。越来越多的证据表明，HA和CD44信号在口腔鳞状细胞癌的发生发展中起重要作用。透明质酸主要由透明质酸合成酶合成，本研究探讨了透明质酸合成酶2(HAS2)在口腔癌进展行为中的作用。
CD44 is a transmembrane receptor found on many different benign and malignant cells. Hyaluronan (HA), a major component of the extracellular matrix, is the primary ligand for CD44 receptors. In cancer cells, HA interaction with CD44 promotes multiple signaling pathways that influence tumor cell progression behaviors in a variety of solid tumors. Increasing evidence indicates that HA and CD44 signaling play an important role in oral cavity squamous cell carcinoma progression. HA is primarily synthesized by hyaluronan synthases, and the current study investigated the role of hyaluronan synthase 2 (HAS 2) in oral cavity carcinoma progression behaviors.