Emergence of Zaire Ebola Virus Disease in Guinea
Emergence of Zaire Ebola Virus Disease in Guinea
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DOI：
10.1056/nejmoa1404505
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发表时间：
2014-10-09
影响因子：
158.5
通讯作者：
Guenther, Stephan
中科院分区：
文献类型：
--
作者：
Baize, Sylvain;Pannetier, Delphine;Guenther, Stephan
2014年3月，世界卫生组织获悉几内亚爆发了一种以发烧、严重腹泻、呕吐和高死亡率为特征的传染病。病毒学调查确定扎伊尔埃博拉病毒（EBOV）为病原体。全长基因组测序和系统发育分析表明，来自几内亚的EBOV与来自刚果民主共和国和加蓬的已知EBOV毒株形成了一个独立的进化枝。流行病学调查将实验室确诊病例与2013年12月爆发的假定首例死亡病例联系起来。这项研究表明，几内亚出现了一种新的EBOV毒株。
In March 2014, the World Health Organization was notified of an outbreak of a communicable disease characterized by fever, severe diarrhea, vomiting, and a high fatality rate in Guinea. Virologic investigation identified Zaire ebolavirus (EBOV) as the causative agent. Full-length genome sequencing and phylogenetic analysis showed that EBOV from Guinea forms a separate clade in relationship to the known EBOV strains from the Democratic Republic of Congo and Gabon. Epidemiologic investigation linked the laboratory-confirmed cases with the presumed first fatality of the outbreak in December 2013. This study demonstrates the emergence of a new EBOV strain in Guinea.