Sexual precocity after immigration from developing countries to Belgium: evidence of previous exposure to organochlorine pesticides
Sexual precocity after immigration from developing countries to Belgium: evidence of previous exposure to organochlorine pesticides
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DOI：
10.1093/humrep/16.5.1020
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发表时间：
2001-05-01
影响因子：
6.1
通讯作者：
Bourguignon, JP
中科院分区：
文献类型：
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作者：
Krstevska-Konstantinova, M;Charlier, C;Bourguignon, JP
在一项对比利时145例性早熟患者进行的为期9年的回顾性生长研究中，28%似乎是外国儿童（39名女孩，1名男孩），他们在4至5年前从22个发展中国家移民过来，与特定的种族或国家背景没有任何联系。这些患者要么是收养的（n = 28），要么是非收养的（n = 12），后者在移民时具有正常的体重和身高，并开始青春期早期，没有早期剥夺的证据，这导致了性早熟的机制可能涉及先前暴露于雌激素性内分泌干扰物的假设。对八种农药进行了毒理学等离子体筛选，检测到了p，p ' -DDE，它是有机氯农药DDT的衍生物。在国外收养的（n = 15）和非收养的（n = 11）性早熟女孩中，p，p ' -DDE浓度中位数分别为1.20和1.04 ng/nnl，而15名比利时本土特发性或器质性早熟女孩中有13名的浓度检测不到（
In a retrospective auxological study of 145 patients seen in Belgium during a 9-year period for treatment of precocious puberty, 28% appeared to be foreign children (39 girls, one boy) who immigrated 4 to 5 years earlier from 22 developing countries, nithout any link to a particular ethnic or country background. The patients were either adopted (n = 28) or non-adopted (n = 12), the latter having normal weight and height at immigration and starting early puberty without evidence of earlier deprivation, This led to the hypothesis that the mechanism of precocious puberty might involve previous exposure to oestrogenic endocrine disrupters. A toxicological plasma screening for eight pesticides detected p,p ' -DDE, which is derived from the organochlorine pesticide DDT. Median p,p ' -DDE concentrations were respectively 1.20 and 1.04 ng/nnl in foreign adopted (n 15) and non-adopted (n = 11) girls with precocious puberty, while 13 out of 15 Belgian native girls with idiopathic or organic precocious puberty showed undetectable concentrations (