Association between immune activation and early depressive symptoms in cancer patients treated with interleukin-2-based therapy
Association between immune activation and early depressive symptoms in cancer patients treated with interleukin-2-based therapy
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DOI：
10.1016/s0306-4530(01)00030-0
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发表时间：
2001-11-01
影响因子：
3.7
通讯作者：
Neveu, PJ
中科院分区：
文献类型：
--
作者：
Capuron, L;Ravaud, A;Neveu, PJ
在 33 名接受细胞因子治疗的癌症患者中研究了免疫激活与早期抑郁症状发展之间的关系。患者接受单独皮下注射 IL-2 (n=13) 或联合 IFN-α (n=5) 治疗，或单独低剂量皮下注射 (n=5) 或高剂量静脉注射 (n=10) 注射 IFN-α。在细胞因子治疗开始前和五天后进行的临床访谈中，使用蒙哥马利和阿斯伯格抑郁评定量表（MADRS）评估抑郁症状的强度。在同一天，采集每位患者的血样以测量细胞因子（IL-6、IL-10、IL-1ra）和细胞因子受体（sIL-2R、LIF-R）的血清浓度。结果显示，接受 IL-2 或 IL-2+IFN-α 治疗的患者在治疗期间表现出伴随的情绪症状和血清细胞因子水平升高。在这些患者中，终点时抑郁症状的强度与基线和终点之间血清 IL-10 水平的增加呈正相关。 IL-10是一种抗炎细胞因子，它是响应促炎细胞因子的产生而产生的，从而反映炎症反应。这些结果支持抑郁症状与细胞因子网络激活之间密切关系的假设。 (C) 2001 Elsevier Science Ltd. 保留所有权利。
The relationship between immune activation and the development of early depressive symptoms were studied in 33 cancer patients undergoing cytokine therapy. Patients were treated either with subcutaneous IL-2 administered alone (n=13) or in association with IFN-alpha (n=5), or with IFN-alpha alone administered subcutaneously at low doses (n=5) or intravenously at high doses (n=10). The intensity of depressive symptoms was assessed during a clinical interview carried out before the start of cytokine therapy and five days later using the Montgomery and Asberg Depression Rating Scale (MADRS). On the same days, blood samples were collected for each patient to measure serum concentrations of cytokines (IL-6, IL-10, IL-1ra) and cytokine-receptors (sIL-2R, LIF-R). Results showed that patients treated with IL-2 or IL-2+IFN-alpha displayed concomitant mood symptoms and increased serum cytokine levels during treatment. In these patients, the intensity of depressive symptoms at endpoint was positively correlated with the increases measured in serum levels of IL-10 between baseline and endpoint. IL-10 is an anti-inflammatory cytokine that is produced in response to the production of proinflammatory cytokines, and thereby reflects an inflammatory response. These results support the hypothesis of close relationship between depressive symptoms and the activation of the cytokine network. (C) 2001 Elsevier Science Ltd. All rights reserved.