Endoreplication and polyploidy: insights into development and disease
Endoreplication and polyploidy: insights into development and disease
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DOI：
10.1242/dev.080531
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发表时间：
2013-01-01
期刊：
影响因子：
4.6
通讯作者：
Duronio, Robert J.
中科院分区：
文献类型：
--
作者：
Fox, Donald T.;Duronio, Robert J.
多倍体细胞的基因组含有典型二倍体染色体数目的倍数，并且在许多不同的生物体中发现。对各种动物和植物发育系统的研究揭示了控制多倍体产生的进化上保守的机制，最近开始为其生理功能提供线索。这些研究表明，细胞多倍性在正常发育过程中起着重要作用，也有助于人类疾病，特别是癌症。
Polyploid cells have genomes that contain multiples of the typical diploid chromosome number and are found in many different organisms. Studies in a variety of animal and plant developmental systems have revealed evolutionarily conserved mechanisms that control the generation of polyploidy and have recently begun to provide clues to its physiological function. These studies demonstrate that cellular polyploidy plays important roles during normal development and also contributes to human disease, particularly cancer.