Efficacy of the red blood cell distribution width for predicting the prognosis of Bell palsy: a pilot study
Efficacy of the red blood cell distribution width for predicting the prognosis of Bell palsy: a pilot study
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红细胞分布宽度预测贝尔麻痹预后的功效：一项初步研究
DOI：
10.1007/s00405-016-4445-z
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发表时间：
2017
影响因子：
2.6
通讯作者：
Ueda Hiromi
中科院分区：
文献类型：
--
作者：
Horibe Yuichiro;Tanigawa Tohru;Shibata Rei;Nonoyama Hiroshi;Kano Fumiya;Yamaguchi Satoshi;Murotani Kenta;Ogawa Takaki;Ueda Hiromi
本研究的目的是调查RDW值和贝尔麻痹患者的预后之间的关系，以寻找一种预测贝尔麻痹恢复的预后生物标志物。我们测量了61例50岁及以下的贝尔麻痹患者的RDW并评估了面部运动。所有患者都接受了类固醇加抗病毒药的治疗。7例患者接受了面神经减压术。在治疗后阶段，Yanagihara分级评分为36或以上的患者被视为恢复满意。根据患者对治疗的反应将其分为两组（恢复和未恢复），并测量包括RDW在内的几个参数以进行进一步分析。未恢复组的RDW值显著高于恢复组（13.5 ± 1.7 vs. 12.7 ± 0.7%，p = 0.046）。在多元逻辑回归模型中，RDW是唯一与Bell麻痹恢复相关的因素（优势比1.93，95%可信区间1.02- 4.65，p = 0.042）。我们的初步研究提供了第一个证据表明，红细胞分布宽度（RDW）可以预测恢复贝尔麻痹患者年龄在50岁及以下。进一步的研究是必要的，以阐明我们的研究结果的潜在病理生理机制。
The aim of this study was to investigate the association between RDW values and the prognosis of patients with Bell palsy in an effort to find a prognostic biomarker that predicts recovery from Bell palsy. We measured RDW and evaluated facial movement in 61 patients with Bell palsy aged 50 years and less. All patients were treated with a steroid plus an antiviral agent. Seven patients underwent surgery for facial nerve decompression. During the post-treatment period, patients with a Yanagihara grading score of 36 or more were regarded as having a satisfactory recovery. Patients were divided into two groups (recovered and unrecovered) according to their response to treatment, and several parameters, including the RDW, were measured for further analysis. RDW values were significantly higher in the unrecovered group than in the recovered group (13.5 ± 1.7 vs. 12.7 ± 0.7%,p= 0.046). In the multiple logistic regression model, RDW was the only factor associated with recovery from Bell palsy (odds ratio 1.93, 95% confidence interval 1.02–4.65,p= 0.042). Our preliminary study provides the first evidence that the red cell distribution width (RDW) can predict recovery from Bell palsy in patients aged 50 years and less. Further studies are necessary to elucidate the potential pathophysiological mechanisms for our findings.