Dual-energy X-ray Absorptiometry is a valid tool for assessing skeletal muscle mass in older women
Dual-energy X-ray Absorptiometry is a valid tool for assessing skeletal muscle mass in older women
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DOI：
10.1093/jn/137.12.2775
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发表时间：
2007-12-01
影响因子：
4.2
通讯作者：
Going, Scott
中科院分区：
文献类型：
--
作者：
Chen, Zhao;Wang, ZiMian;Going, Scott
评估骨骼肌质量（SMM）是研究和检测肌肉减少症的关键。通过MRI或计算机断层扫描直接测量是昂贵的或高辐射暴露。双能X线吸收法（DXA）是有前途的身体成分评估，但DXA预测老年人SMM的有效性仍在调查中。本研究的目的是评估DXA衍生的测量瘦软组织质量（LSTM）和老年妇女SMM之间的关系。研究参与者是在亚利桑那州南部招募的绝经后妇女（n = 101）。使用MRI和DXA（QDR 4500 w）测量全身和局部身体成分。参与者的平均年龄为70.7 ± 6.4岁，平均BMI为27.4 ± 5.1 kg/m（2）。全身（r = 0.94; P < 0.001）和腿部（r = 0.91; P <0.001）的DXA衍生LSTM与MRI衍生SMM高度相关。在多变量模型中，调整年龄和DXA衍生的脂肪百分比略微增加了SMM的方差，这可以通过DXA衍生的腿部LSTIM评估来解释，但不是全身。总之，尽管DXA测量和MRI导出的SMM之间的关系因感兴趣区域而异，但DXA对SMM的总体预测是极好的。我们得出结论，DXA是一种可靠的方法，横截面评估SMM老年妇女。
Assessing skeletal muscle mass (SMM) is critical in studying and detecting sarcopenia. Direct measurements by MRI or computerized tomography are expensive or high in radiation exposure. Dual-energy X-ray absorptiometry (DXA) is promising for body composition assessments, but the validity of DXA for predicting SMM in the elderly is still under investigation. The objective of this study was to assess the relationship between DXA-derived measurements of lean soft tissue mass (LSTM) and SMM in older women. Study participants were postmenopausal women (n = 101) recruited in southern Arizona. Total and regional body composition was measured using MRI and DXA (QDR4500w). The participants' mean age was 70.7 +/- 6.4 y and their mean BMI was 27.4 +/- 5.1 kg/m(2). DXA-derived LSTM was highly correlated with MRI-derived SMM for the whole body (r = 0.94; P < 0.001) and leg region (r = 0.91; P < 0.001). In multivariate models, adjusting for age and DXA-derived percent fat slightly increased the amount of variance in SMM that can be explained by the DXA-derived LSTIM assessments for the leg region but not for the total body. In conclusion, although the relationships between DXA measures and MRI-derived SMM vary by region of interest, the overall prediction of SMM by DXA is excellent. We conclude that DXA is a reliable method for cross-sectional assessments of SMM in older women.