Addendum guidelines for the prevention of peanut allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases-sponsored expert panel
Addendum guidelines for the prevention of peanut allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases-sponsored expert panel
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DOI：
10.1186/s40413-016-0137-9
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发表时间：
2017-01-06
影响因子：
5.1
通讯作者：
Boyce, Joshua A.
中科院分区：
文献类型：
--
作者：
Togias, Alkis;Cooper, Susan F.;Boyce, Joshua A.
背景资料：食物过敏是一个重要的公共卫生问题，因为它影响儿童和成人，可能是严重的，甚至危及生命，并可能在患病率上升。从2008年开始，国家过敏和传染病研究所与其他组织和倡导团体合作，领导制定了第一个诊断和管理食物过敏的临床指南。最近一项具有里程碑意义的临床试验和其他新出现的数据表明，花生过敏可以通过在婴儿期开始引入含花生的食物来预防。目的：根据这些发现，沿着25个专业组织、联邦机构和患者倡导团体，国家过敏和传染病研究所促进了补充指南的发展，专门针对花生过敏的预防。结果：该附录为处于花生过敏发展风险水平的婴儿提供了3个单独的指南，旨在供各种医疗保健提供者使用。讨论的主题包括风险类别的定义，适当使用测试（特异性IgE测量，皮肤点刺试验和口服食物挑战），以及在卫生保健提供者的办公室或家中引入含花生食品的时机和方法。附录指南提供的背景，理由，和强度的证据each recommendation.Conclusions：指南已经制定了早期引入含花生的食物到婴儿的饮食中的各种风险水平的花生过敏。
Background: Food allergy is an important public health problem because it affects children and adults, can be severe and even life-threatening, and may be increasing in prevalence. Beginning in 2008, the National Institute of Allergy and Infectious Diseases, working with other organizations and advocacy groups, led the development of the first clinical guidelines for the diagnosis and management of food allergy. A recent landmark clinical trial and other emerging data suggest that peanut allergy can be prevented through introduction of peanut-containing foods beginning in infancy.Objectives: Prompted by these findings, along with 25 professional organizations, federal agencies, and patient advocacy groups, the National Institute of Allergy and Infectious Diseases facilitated development of addendum guidelines to specifically address the prevention of peanut allergy.Results: The addendum provides 3 separate guidelines for infants at various risk levels for the development of peanut allergy and is intended for use by a wide variety of health care providers. Topics addressed include the definition of risk categories, appropriate use of testing (specific IgE measurement, skin prick tests, and oral food challenges), and the timing and approaches for introduction of peanut-containing foods in the health care provider's office or at home. The addendum guidelines provide the background, rationale, and strength of evidence for each recommendation.Conclusions: Guidelines have been developed for early introduction of peanut-containing foods into the diets of infants at various risk levels for peanut allergy.