SerbGO: searching for the best GO tool.
SerbGO: searching for the best GO tool.
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DOI：
10.1093/nar/gkn256
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发表时间：
2008-07-01
影响因子：
14.9
通讯作者：
Sánchez-Pla A
中科院分区：
文献类型：
--
作者：
Mosquera JL;Sánchez-Pla A
近年来，科学界提供了许多工具来辅助通路分析。其中一些程序可用于管理基因产物的功能注释，其他程序则面向探索和分析数据集，许多程序允许两种可能性。这些工具的潜在用户必须决定现有程序中哪一个最适合他们的需要。SerbGO是一个用户友好的web工具，旨在促进这项任务。它可以用于(i)搜索特定的功能并确定哪些应用程序提供这些功能，以及（ii）根据不同类型的功能比较几个应用程序。迭代和组合这两种功能可以很容易地选择合适的工具。SerbGO所需的数据要么是定义的Standard Functionalities Set中的所需功能，要么是要比较的工具列表。所执行的分析执行交叉分类，生成易于阅读的输出，其中包含实现所需功能的工具列表，或包含希望进行比较的GO工具分类的表。SerbGO是免费的，不需要登录。可以直接访问我们的服务器（http://estbioinfo.stat.ub.es/apli/serbgo）或GO联盟网站（http://www.geneontology.org/GO.tools.microarray.shtml#serbgo）。
In recent years, the scientific community has provided many tools to assist with pathway analysis. Some of these programs can be used to manage functional annotation of gene products, others are oriented to exploring and analyzing data sets and many allow both possibilities. Potential users of these tools are faced with the necessity to decide which of the existing programs are the most appropriate for their needs. SerbGO is a user-friendly web tool created to facilitate this task. It can be used (i) to search for specific functionalities and determine which applications provide them and (ii) to compare several applications on the basis of different types of functionalities. Iterating and combining both functionalities can easily lead to selecting an appropriate tool. Data required by SerbGO is either the desired capabilities within a defined Standard Functionalities Set or the list of the tools to be compared. The analysis performed carries out a cross-classification that produces an easily readable output with the list of tools that implement the capabilities demanded or a table with the categorization of the GO tools that one wishes to compare. SerbGO is freely available and does not require a login. It can be accessed either directly at our server (http://estbioinfo.stat.ub.es/apli/serbgo) or at the GO Consortium website (http://www.geneontology.org/GO.tools.microarray.shtml#serbgo).