Altered body composition in type 2 diabetes mellitus
Altered body composition in type 2 diabetes mellitus
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DOI：
10.1038/sj.ijo.0803802
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发表时间：
2008-05-01
影响因子：
4.9
通讯作者：
Schwartz, A. V.
中科院分区：
文献类型：
--
作者：
Heshka, S.;Ruggiero, A.;Schwartz, A. V.
目的：通过对患有和不患有 2 型糖尿病的受试者进行横断面研究，确定脂肪和瘦肉软组织的数量和分布差异，并确定任何差异是否受到种族/民族或性别的影响。设计和方法：超重和肥胖（体重指数，BMI >= 25 kg m(-2)）患有 2 型糖尿病的黑人、白人和西班牙裔男性 (490) 和女性 (825)（（平均值 +/- 标准差）年龄 58.5 +/- 6.6；BMI 35.3 +/- 5.3）在参加 Look AHEAD 临床试验时进行了基线双能 X 射线吸收测定全身扫描，以及 242 名健康对照者，其中 91 名男性和 151 名女性（年龄 55.3 +/- 8.6 岁，BMI 30.7 +/- 4.2 kg m(-2)）参加了不相关的研究并接受了扫描结果：根据性别、年龄、种族、临床部位和体型进行调整后，2 型糖尿病患者的总脂肪量小于对照组（-1.4 +/- 0.3（s.e）；34.5 vs 35.8 kg，P
Objective: To identify differences in amount and distribution of fat and lean soft tissue in a cross-sectional study of subjects with and without type 2 diabetes and to determine whether any differences are affected by race/ethnicity or sex.Design and methods: Overweight and obese (body mass index, BMI >= 25 kg m(-2)) Black, White and Hispanic men (490) and women (825) with type 2 diabetes ((mean +/- s.d.) age 58.5 +/- 6.6; BMI 35.3 +/- 5.3) who had a baseline dual energy X-ray absorptiometry whole-body scan at the time of enrollment in the Look AHEAD clinical trial, and 242 healthy controls, 91 males and 151 females (age 55.3 +/- 8.6 years, BMI 30.7 +/- 4.2 kg m(-2)) who were participating in unrelated research and were scanned on the same densitometers.Results: Adjusted for gender, age, race, clinical site and body size, total fat mass was smaller in persons with type 2 diabetes than in controls (-1.4 +/- 0.3 (s.e.); 34.5 vs 35.8 kg, P