A comparative study of betaxolol and dorzolamide effect on ocular circulation in normal-tension glaucoma patients
A comparative study of betaxolol and dorzolamide effect on ocular circulation in normal-tension glaucoma patients
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DOI：
10.1016/s0161-6420(99)00093-7
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发表时间：
2000-03-01
期刊：
影响因子：
13.7
通讯作者：
Martin, B
中科院分区：
文献类型：
--
作者：
Harris, A;Arend, O;Martin, B
目的：确定选择性P-阻滞剂(倍他洛尔)和局部碳酸酐酶抑制剂(多唑胺)的剂量是否对视网膜和球后循环有相似或不同的影响。设计：平衡交叉，开放使用药物。参与者9例正常眼压性青光眼(NTG)患者，干预：经过3周的药物洗脱，NTG患者在治疗1个月后进行研究，测定眼压、视网膜和球后血流动力学，主要观察指标：在基线和用药后，结果：倍他洛尔和多唑胺均能显著降低眼压，且在注射后2周时变化明显且最大(P<；相比之下，多唑胺(而不是倍他洛尔)加速了荧光素在视网膜下象限的动静脉通道(P<；0.05)。治疗2周或4周后，两种药物均不影响颞叶上视网膜的动静脉通道，也不影响视网膜中央动脉或眼动脉的血流速度。结论：虽然多唑胺和倍他洛尔都是有效的降压药，且局部滴注均不影响球后血流动力学，但单独应用多唑胺可加速颞下视网膜的染料转运。(C)2000年由美国眼科学会授予。
Objective: To determine whether dosages of a selective P-blocking agent (betaxolol) and a topical carbonic anhydrase inhibitor (dorzolamide), sufficient to significantly lower intraocular pressure (IOP), have similar or disparate impact on the retinal and retrobulbar circulation.Design: Counterbalanced crossover, with open-label use of medications.Participants Nine persons with normal-tension glaucoma (NTG),intervention: After a 3-week drug washout, NTG patients were studied after 1 month of treatment with either dorzolamide or betaxolol, with determinations of IOP and retinal and retrobulbar hemodynamics,Main Outcome Measures: At baseline and after treatment with each drug, retinal arteriovenous passage time was determined by scanning laser ophthalmoscopy after fluorescein dye injection, and flow velocities in the central retinal and ophthalmic arteries were measured with color Doppler ultrasonography imaging.Results: Betaxolol and dorzolamide each lowered IOP significantly, with these changes apparent and maximal after 2 weeks (each P < 0.05), In contrast, dorzolamide (but not betaxolol) accelerated arteriovenous passage of fluorescein dye in the inferior temporal quadrant of the retina (P < 0.05). Neither drug affected arteriovenous passage in the superotemporal retina or any aspect of central retinal or ophthalmic artery flow velocity after either 2 or 4 weeks.Conclusions: Although both dorzolamide and betaxolol are effective ocular hypotensive agents and their topical instillation leaves retrobulbar hemodynamics unaltered, dorzolamide alone accelerates inferotemporal retinal dye transit. (C) 2000 by the American Academy of Ophthalmology.