Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP)
Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP)
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DOI：
10.1016/s0140-6736(06)69041-7
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发表时间：
2006-07-15
期刊：
影响因子：
168.9
通讯作者：
Charman, Tony
中科院分区：
文献类型：
--
作者：
Baird, Gillian;Simonoff, Emily;Charman, Tony
背景最近的报告表明，自闭症和相关谱系障碍（ASD）的患病率大大高于以前的认识。我们试图量化的患病率ASD儿童在南泰晤士，英国。方法在一个总人口队列的56946名9-10岁的儿童，我们筛选所有这些目前的临床诊断ASD（n=255）或那些被判定为有风险的未被发现的情况下（n=1515）。分层的子样本（n=255）接受了全面的诊断评估，包括标准化的临床观察，自闭症症状，语言和智商（IQ）的家长访谈评估。儿童孤独症和其他ASD的临床共识诊断。我们使用了一个样本加权程序估计prevalence.Findings儿童孤独症的患病率为38.9每10000（95%CI 29.9-47.8）和其他ASD的患病率为77.2每10000（52.1-102.3），使所有AS Ds的总患病率为116.1每10000（90.4-141.8）。儿童孤独症的狭义定义，结合临床共识与过去和现在表现的工具标准，提供了每10000人24.8（17.6-32.0）的患病率。以前的本地识别率是最低的受教育程度较低的父母。自闭症和相关的ASD的解释患病率大大高于以前承认。这种增加是否是由于更好的确定，扩大诊断标准，或发病率增加尚不清楚。卫生、教育和社会护理服务需要认识到患有某种形式ASD的儿童的需求，这些儿童占儿童人口的1%。
Background Recent reports have suggested that the prevalence of autism and related spectrum disorders (ASDs) is substantially higher than previously recognised. We sought to quantify prevalence of ASDs in children in South Thames, UK.Methods Within a total population cohort of 56946 children aged 9-10 years, we screened all those with a current clinical diagnosis of ASD (n=255) or those judged to be at risk for being an undetected case (n=1515). A stratified subsample (n=255) received a comprehensive diagnostic assessment, including standardised clinical observation, and parent interview assessments of autistic symptoms, language, and intelligence quotient (IQ). Clinical consensus diagnoses of childhood autism and other ASDs were derived. We used a sample weighting procedure to estimate prevalence.Findings The prevalence of childhood autism was 38.9 per 10000 (95% CI 29.9-47.8) and that of other ASDs was 77.2 per 10000 (52.1-102.3), making the total prevalence of all AS Ds 116.1 per 10000 (90.4-141.8). A narrower definition of childhood autism, which combined clinical consensus with instrument criteria for past and current presentation, provided a prevalence of 24.8 per 10 000 (17.6-32.0). The rate of previous local identification was lowest for children of less educated parents.Interpretation Prevalence of autism and related ASDs is substantially greater than previously recognised. Whether the increase is due to better ascertainment, broadening diagnostic criteria, or increased incidence is unclear. Services in health, education, and social care will need to recognise the needs of children with some form of ASD, who constitute 1% of the child population.