Women and HIV infection: a cohort study of 483 HIV-infected women in Bordeaux, France, 1985-1991. The Groupe d'Epidémiologie Clinique du SIDA en Aquitaine.
Women and HIV infection: a cohort study of 483 HIV-infected women in Bordeaux, France, 1985-1991. The Groupe d'Epidémiologie Clinique du SIDA en Aquitaine.
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妇女与艾滋病毒感染：1985-1991 年阿基坦 SIDA 流行病学诊所对法国波尔多 483 名艾滋病毒感染妇女进行的队列研究。
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
F. Dabis
中科院分区：
文献类型：
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作者：
Philippe Morlat;P. Parneix;D. Douard;D. Lacoste;M. Dupon;G. Chêne;J. Pellegrin;J. Ragnaud;F. Dabis
目的
研究女性艾滋病病毒（HIV）感染的流行病学趋势、临床模式、病情演变及预后。
设计
对1816名HIV感染患者进行队列研究。
结果
截至1991年1月1日，向阿基坦艾滋病临床流行病学小组监测系统报告的患者中有483人（26.6%）为女性。随着时间推移，男女比例逐渐下降（1985年为3.4∶1；1990年为2.7∶1）。50%的HIV感染女性是或曾经是静脉吸毒者（IVDU）。在过去5年中，经异性性传播感染HIV的比例从11.6%上升至34.6%；通过异性性交感染的女性中有46.9%报告与男性静脉吸毒者有性接触。除卡波西肉瘤外，在艾滋病定义性疾病的总体分布上，男女之间未观察到显著差异。在控制预后变量后，女性相较于男性艾滋病进展较慢的观察趋势消失。然而，在多变量分析中，女性性别在艾滋病确诊后显著提高了生存率（相对危险度为2.7；95%置信区间为1.1 - 6.2）。
结论
在工业化国家和发展中国家，女性患者HIV感染的早期诊断以及女性中HIV感染的预防现在是公共卫生干预的重点。
OBJECTIVES
To study the epidemiological trends, clinical patterns, evolution and prognosis of HIV infection in women.
DESIGN
Cohort study of 1816 HIV-infected patients.
RESULTS
Up to 1 January 1991, 483 (26.6%) of the patients reported to the Groupe d'Epidemiologie Clinique du SIDA en Aquitaine surveillance system were women. The male-to-female ratio has decreased progressively (3.4:1 in 1985; 2.7:1 in 1990) over time. Fifty per cent of HIV-infected women are or have been intravenous drug users (IVDU). The proportion of heterosexually acquired HIV infection increased from 11.6 to 34.6% over the last 5 years; 46.9% of the women infected through heterosexual intercourse reported sexual contacts with male IVDU. Excluding Kaposi's sarcoma, no significant difference was observed between men and women in the overall distribution of AIDS-defining events. The observed trend of a slower progression to AIDS in women, compared with men, disappeared when controlling for prognostic variables. However, female sex significantly enhanced survival after AIDS diagnosis in multivariate analysis (relative risk, 2.7; 95% confidence interval, 1.1-6.2).
CONCLUSION
Early diagnosis of HIV infection in female patients and prevention of HIV infection among women is now a priority for public health interventions, both in industrialized and in developing countries.