Beta-adrenergic receptor regulation of growth factor protein levels in human choroidal endothelial cells.
Beta-adrenergic receptor regulation of growth factor protein levels in human choroidal endothelial cells.
复制标题
β-肾上腺素能受体对人脉络膜内皮细胞生长因子蛋白水平的调节。
DOI：
10.1080/08977190802442070
复制
发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Jiang,Youde
中科院分区：
文献类型：
--
作者：
Steinle,JenaJ;CappociaJr,FrankC;Jiang,Youde
Remodeling of the choroidal vasculature is a prominent factor in age-related macular degeneration. While many of the growth factors involved in this vascular remodeling are known, their regulation remains much less so. The hypothesis of the present study was that stimulation of human choroidal endothelial cells with the beta-adrenergic receptor agonist isoproterenol would lead to an increase in pigment epithelial derived factor (PEDF) and angiopoietin 1 (Ang1), markers of a stable vasculature. Protein levels of PEDF and Ang1 were significantly increased following stimulation with isoproterenol. However, isoproterenol also significantly increased protein levels of vascular endothelial cell growth factor, which is active during vasculature remodeling. These data suggest that beta-adrenergic receptor agonists are likely upstream of a number of growth factors implicated in ocular disease and have multiple effects on choroidal endothelial cells. Modulation of this signaling in the choroid may offer a new avenue for therapeutics.
