Lung parenchymal shear modulus, airway wall remodeling, and bronchial hyperresponsiveness
Lung parenchymal shear modulus, airway wall remodeling, and bronchial hyperresponsiveness
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DOI：
10.1152/jappl.1997.83.1.140
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发表时间：
1997-07-01
影响因子：
3.3
通讯作者：
Pare, PD
中科院分区：
文献类型：
--
作者：
Lambert, RK;Pare, PD
当气道变窄时，无论是通过平滑肌缩短的作用还是在强制呼气期间，肺实质局部扭曲并提供抵抗变窄的增加的支气管周围应力。虽然这种相互依赖性已经得到了很好的研究，气道重塑相互依赖的定量意义尚未阐明。我们使用了一种改进的支气管对平滑肌激动剂反应的计算模型来研究在肺反冲压为4、5和8 cmH（2）O时气道狭窄（如气道阻力所示）、实质剪切模量、外膜增厚和内壁增厚之间的关系。我们发现，在低反冲压力下，实质剪切模量的降低具有与气道壁中度增厚相当的显著效果。在较高的肺反冲压力下，该影响可以忽略不计。
When airways narrow, either through the action of smooth muscle shortening or during forced expiration, the lung parenchyma is locally distorted and provides an increased peribronchial stress that resists the narrowing. Although this interdependence has been well studied, the quantitative significance of airway remodeling to interdependence has not been elucidated. We have used an improved computational model of the bronchial response to smooth muscle agonists to investigate the relationships between airway narrowing (as indicated by airway resistance), parenchymal shear modulus, adventitial thickening, and inner wall thickening at lung recoil pressures of 4, 5, and 8 cmH(2)O. We have found that, at low recoil pressures, decreases in parenchymal shear modulus have a significant effect that is comparable to that of moderate thickening of the airway wall. At higher lung recoil pressures, the effect is negligible.