Cystic fibrosis carriership and tuberculosis: hints toward an evolutionary selective advantage based on data from the Brazilian territory
Cystic fibrosis carriership and tuberculosis: hints toward an evolutionary selective advantage based on data from the Brazilian territory
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DOI：
10.1186/s12879-017-2448-z
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发表时间：
2017-05-12
影响因子：
3.7
通讯作者：
Ferreira da Silva Filho, Luiz Vicente Ribeiro
中科院分区：
文献类型：
--
作者：
Bosch, Lander;Bosch, Barbara;Ferreira da Silva Filho, Luiz Vicente Ribeiro
背景：囊性纤维化（CF）是白种人中最常见的致命性遗传病，其原因尚未完全研究。我们的目的是深化的假设，CF载体有一个相对的保护结核分枝杆菌（Mtb）infection.Methods：应用空间流行病学，我们研究了CF carriership率和结核病（TB）在巴西的发病率之间的联系。我们校正了5个潜在的环境和2个免疫学混杂因素：月收入，卫生设施，识字率，种族组成和人口密度，沿着艾滋病发病率和2型糖尿病。吸烟数据是不完整的，不能用于analysis.Results：CF携带率和TB发病率之间的显着，负相关，独立的7个混杂因素被发现.Conclusion：我们提供了探索性的支持，携带一个单一的CFTR突变武器对结核分枝杆菌感染的假设。
Background: The reason why Cystic Fibrosis (CF) is the most common fatal genetic disease among Caucasians has been incompletely studied. We aimed at deepening the hypothesis that CF carriers have a relative protection against Mycobacterium tuberculosis(Mtb) infection.Methods: Applying spatial epidemiology, we studied the link between CF carriership rate and tuberculosis ( TB) incidence in Brazil. We corrected for 5 potential environmental and 2 immunological confounders in this relation: monthly income, sanitary provisions, literacy rates, racial composition and population density along with AIDS incidence rates and diabetes mellitus type 2. Smoking data were incomplete and not available for analysis.Results: A significant, negative correlation between CF carriership rate and TB incidence, independent of any of the seven confounders was found.Conclusion: We provide exploratory support for the hypothesis that carrying a single CFTR mutation arms against Mtb infections.