A unifying family of group sequential test designs
A unifying family of group sequential test designs
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DOI：
10.1111/j.0006-341x.1999.00874.x
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发表时间：
1999-09-01
期刊：
影响因子：
1.9
通讯作者：
Emerson, SS
中科院分区：
文献类型：
--
作者：
Kittelson, JM;Emerson, SS
目前，分组序贯临床试验的设计需要在几个不同的设计类别、设计规模和确定停止规则的策略中进行选择。这种方法可能会限制设计选择过程，从而使临床问题得不到充分解决。这篇文章描述了一系列的设计，它统一了以前的方法，并允许在以前的类别之间连续移动。这种统一的方法促进了定制设计以解决重要的临床问题的过程。统一设计族是由四边界组序列设计的推广而成的，其中每个边界的形状和位置可以独立指定。描述了使用误差花费函数实现该设计的方法。文中还给出了使用该设计族的实例。
Currently, the design of group sequential clinical trials requires choosing among several distinct design categories, design scales, and strategies for determining stopping rules. This approach can limit the design selection process so that clinical issues are not fully addressed. This paper describes a family of designs that unifies previous approaches and allows continuous movement among the previous categories. This unified approach facilitates the process of tailoring the design to address important clinical issues. The unified family of designs is constructed from a generalization of a four-boundary group sequential design in which the shape and location of each boundary can bt: independently specified. Methods for implementing the design using error-spending functions are described. Examples illustrating the use of the design family are also presented.