A Tracer-Kinetic Field Theory for Medical Imaging
A Tracer-Kinetic Field Theory for Medical Imaging
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DOI：
10.1109/tmi.2014.2300450
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发表时间：
2014-04-01
影响因子：
10.6
通讯作者：
Sourbron, Steven
中科院分区：
文献类型：
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作者：
Sourbron, Steven
动态成像数据，目前分析与示踪剂动力学理论开发的个人时间曲线测量整个器官。假设体素表示所有通过相同动脉入口接收指示剂的孤立系统。这会导致众所周知的系统错误，但也未能利用数据的空间结构。在这项研究中，一个更一般的理论框架，充分利用图像数据的特定结构。该理论编码的事实，体素接收指示剂从他们的直接邻居，而不是从上游动脉输入。这导致示踪剂动力学场理论，其中组织参数是可以通过分析浓度的时间和空间模式来测量的空间的函数。的影响进行评估，通过一些常见的组织类型的字段模型。示踪剂-动力学场理论的关键益处在于：1）可以校正长期存在的系统误差，特别是团分散和大血管血流对组织灌注测量的污染的问题; 2）可以测量表征体素之间的对流或扩散交换的附加组织参数; 3）可以消除测量单独的动脉输入函数的需要。
Dynamic imaging data are currently analyzed with a tracer-kinetic theory developed for individual time curves measured over whole organs. The assumption is that voxels represent isolated systems which all receive indicator through the same arterial inlet. This leads to well-known systematic errors, but also fails to exploit the spatial structure of the data. In this study, a more general theoretical framework is developed which makes full use of the specific structure of image data. The theory encodes the fact that voxels receive indicator from their immediate neighbors rather than from an upstream arterial input. This results in a tracer-kinetic field theory where the tissue parameters are functions of space which can be measured by analyzing the temporal and spatial patterns in the concentrations. The implications are evaluated through a number of field models for common tissue types. The key benefits of a tracer-kinetic field theory are that: 1) long-standing systematic errors can be corrected, specifically the issue of bolus dispersion and the contamination of large-vessel blood flow on tissue perfusion measurements; 2) additional tissue parameters can be measured that characterize convective or diffusive exchange between voxels; 3) the need to measure a separate arterial input function can be eliminated.