Selective location of palisaded myofibroblastoma with amianthoid fibres.
Selective location of palisaded myofibroblastoma with amianthoid fibres.
复制标题
具有石榴石纤维的栅栏状肌纤维母细胞瘤的选择性定位。
DOI：
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发表时间：
1991
影响因子：
3.4
通讯作者：
F. Filippo
中科院分区：
文献类型：
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作者：
G. Bigotti;A. Coli;M. Mottolese;F. Filippo
发生栅栏状肌纤维母细胞瘤与amianthoid纤维在左腹股沟淋巴结的51岁男子促使调查的因素，其唯一的位置。对抗原谱进行了表征，证实了波形蛋白和平滑肌肌动蛋白的均匀表达以及结蛋白的缺乏。使用单克隆抗体来检查肌成纤维细胞和栅栏状肌成纤维细胞瘤的假定起源细胞的差异分布，表明腹股沟淋巴结具有丰富的波形蛋白和肌动蛋白阳性细胞和结蛋白阴性细胞。这表明肌纤维母细胞瘤的选择性发生与淋巴结微环境有关，提供了可用和潜在增殖的肌纤维母细胞的来源。肥大细胞丰富的病变，特别是周围的amanthoid纤维，以及在盆腔和腹股沟淋巴结。考虑到肥大细胞在间质基质降解中的已知作用，假定类石棉纤维的核心代表降解的间质基质，类似于上述淋巴结组中常见的scaffold区域，而该实体特有的外周辐条是波形蛋白和平滑肌肌动蛋白的结果，直接由增殖的肌成纤维细胞脱落。
The occurrence of a palisaded myofibroblastoma with amianthoid fibres in the left inguinal lymph node of a 51 year old man prompted an investigation of the factors underlying its exclusive location. The antigen profile was characterised which confirmed the homogeneous expression of vimentin and smooth muscle actin as well as the lack of desmin. Use of monoclonal antibodies to check for a differential distribution of myofibroblasts and the putative cell of origin of palisaded myofibroblastoma showed that inguinal lymph nodes have abundant vimentin and actin positive cells and desmin negative cells. This suggests that the selective occurrence of myofibroblastoma is related to the nodal microenvironment, providing a source of available and potentially proliferating myofibroblasts. Mast cells abounded in this lesion, particularly around amianthoid fibres, as well as in pelvic and inguinal lymph nodes. In view of the known role of mast cells in interstitial matrix degradation it is postulated that the core of amianthoid fibres represents degraded interstitial matrix, analogous to the sclerotic areas commonly found in the above mentioned lymph node groups, while the peripheral spokes, so peculiar to this entity, are the result of vimentin and smooth muscle actin, directly shed by proliferating myofibroblasts.