Tertiary intratumor lymphoid tissue in colo-rectal cancer.
Tertiary intratumor lymphoid tissue in colo-rectal cancer.
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DOI：
10.3390/cancers4010001
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发表时间：
2011-12-28
期刊：
影响因子：
5.2
通讯作者：
Marchesi F
中科院分区：
文献类型：
--
作者：
Bergomas F;Grizzi F;Doni A;Pesce S;Laghi L;Allavena P;Mantovani A;Marchesi F
异位（或三级）淋巴组织发生在非淋巴器官的炎症或感染部位，并与慢性炎症有关。在结肠粘膜中，小淋巴聚集体已经存在于稳态条件下，作为肠道相关淋巴组织的一部分，并在对粘膜微环境扰动的免疫应答中发挥重要作用。尽管炎症在肿瘤进展中的作用是公认的，但对淋巴组织在癌症中的存在和生物学功能的研究很少。我们在人结直肠癌标本中发现了类似三级淋巴组织的淋巴细胞聚集体;淋巴细胞的瘤内积聚显示出高度的区室化，包括B和T细胞、成熟树突状细胞和CD 21+滤泡树突状细胞（FDC）网络。我们分析了结肠炎相关癌（AOM/DSS）小鼠模型中结肠淋巴组织的适应性。在该模型中，在与肠肿瘤相关的慢性炎症的背景下，B细胞滤泡形成增加。存在围绕B细胞滤泡的淋巴管和血管网络，包括高内皮微静脉（HEV）。未来的任务是确定淋巴组织是否有助于肿瘤相关炎症反应的持续，而不是代表功能性免疫区室，可能参与抗肿瘤反应。
Ectopic (or tertiary) lymphoid tissue develops at sites of inflammation or infection in non lymphoid organs and is associated with chronic inflammation. In colon mucosa, small lymphoid aggregates are already present in homeostatic conditions, as part of the gut-associated lymphoid tissue and play an essential role in the immune response to perturbations of the mucosal microenvironment. Despite the recognized role of inflammation in tumor progression, the presence and biological function of lymphoid tissue in cancer has been poorly investigated. We identified aggregates of lymphocytes resembling tertiary lymphoid tissue in human colorectal cancer specimens; intratumor accumulations of lymphocytes display a high degree of compartmentalization, with B and T cells, mature dendritic cells and a network of CD21+ follicular dendritic cells (FDC). We analyzed the adaptation of colon lymphoid tissue in a murine model of colitis-associated cancer (AOM/DSS). B cell follicle formation increases in the context of the chronic inflammation associated to intestinal neoplasia, in this model. A network of lymphatic and haematic vessels surrounding B cell follicles is present and includes high endothelial venules (HEV). Future task is to determine whether lymphoid tissue contributes to the persistence of the tumor-associated inflammatory reaction, rather than represent a functional immune compartment, potentially participating to the anti tumor response.