Imaging of onset and progression of Alzheimer's disease with voxel-compression mapping of serial magnetic resonance images
Imaging of onset and progression of Alzheimer's disease with voxel-compression mapping of serial magnetic resonance images
复制标题
DOI：
10.1016/s0140-6736(01)05408-3
复制
发表时间：
2001-07-21
期刊：
影响因子：
168.9
通讯作者：
Rossor, MN
中科院分区：
文献类型：
--
作者：
Fox, NC;Crum, WR;Rossor, MN
研究背景早期诊断和监测阿尔茨海默病的进展对于制定治疗策略非常重要。为了检测最早的大脑结构变化，需要在症状出现之前对个体进行研究。我们使用了一种成像技术，称为体素压缩映射局部进行性萎缩的患者与临床前Alzheimer's disease.Methods四个人从家庭与早发性阿尔茨海默病与已知的常染色体显性突变进行了连续的磁共振成像（MRI）超过5-8年。所有4例患者在随访期间均出现症状。20名临床诊断为可能的阿尔茨海默病的个体和20名对照参与者也进行了系列MR成像。应用非线性流体匹配算法将重复扫描配准到基线成像上。雅可比行列式被用来创建体素压缩maps.Findings渐进性萎缩揭示在症状前的个人，与后扣带回和新皮质颞顶皮质的损失，内侧颞叶萎缩。在已知的阿尔茨海默氏病患者中，萎缩是广泛的，除了在初级运动和感觉皮质和小脑，反映了临床phenomenology.Interpretation体素压缩图证实了早期参与内侧颞叶，但也显示后扣带回和颞顶皮质的损失在症状前阶段。该技术可用于诊断和监测治疗干预的效果。
Background Early diagnosis and monitoring of the progression of Alzheimer's disease is important for the development of therapeutic strategies. To detect the earliest structural brain changes, individuals need to be studied before symptom onset. We used an imaging technique known as voxel-compression mapping to localise progressive atrophy in patients with preclinical Alzheimer's disease.Methods Four symptom-free individuals from families with early-onset Alzheimer's disease with known autosomal dominant mutations underwent serial magnetic resonance imaging (MRI) over 5-8 years. All four became symptomatic during follow-up. 20 individuals with a clinical diagnosis of probable Alzheimer's disease and 20 control participants also underwent serial MR imaging. A non-linear fluid matching algorithm was applied to register repeat scans onto baseline imaging. Jacobian determinants were used to create the voxel-compression maps.Findings Progressive atrophy was revealed in presymptomatic individuals, with posterior cingulate and neocortical temporoparietal cortical losses, and medial temporal-lobe atrophy. In patients with known Alzheimer's disease, atrophy was widespread apart from in the primary motor and sensory cortices and cerebellum, reflecting the clinical phenomenology.Interpretation Voxel-compression maps confirmed early involvement of the medial temporal lobes, but also showed posterior cingulate and temporoparietal cortical losses at presymptomatic stage. This technique could be applied diagnostically and used to monitor the effects of therapeutic intervention.