Clinical efficacy of 5-fluorouracil (5-FU) topical cream for treatment of cholesteatoma
Clinical efficacy of 5-fluorouracil (5-FU) topical cream for treatment of cholesteatoma
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DOI：
10.1016/j.anl.2005.05.015
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发表时间：
2005-12-01
影响因子：
1.7
通讯作者：
Takasaki, K
中科院分区：
文献类型：
--
作者：
Takahashi, H;Funabiki, K;Takasaki, K
目的：为明确市售5-氟尿嘧啶（5-FU）外用乳膏的临床疗效，进行临床研究。方法：将2～3立方毫米的5-氟尿嘧啶（5-FU）外用乳膏（协和、罗氏）涂抹于50例各类胆脂瘤（50例患者），涂抹2～5次，间隔2周，按我们制定的标准评价其临床疗效。结果：总计59%的患者胆脂瘤效果较好，其中29%效果一般，其余12%效果较差。它对 EAC 胆脂瘤、伴有充气乳突的阁楼胆脂瘤和复发型胆脂瘤特别有效。结论：5-FU 外用乳膏对于治疗胆脂瘤似乎有效。 (c) 2005 Elsevier Ireland Ltd. 保留所有权利。
Objective: In order to clarify clinical efficacy of commercially available 5-fluorouracil (5-FU) topical cream, a clinical study was conducted.Methods: Two to three cubic millimetres of 5-FU topical cream (Kyowa, Roche) was applied on 50 cases of various types of cholesteatoma (50 patients) two to five times with the interval of 2 weeks, and its clinical efficacy was evaluated by the criteria we developed.Results: In total, 59% of the cholesteatomas showed good effect, 29% of them showed fair effect, and the effect was poor in the remaining 12%. It was particularly effective in cholesteatomas in the EAC, attic cholesteatomas with an aerated mastoid, and in recurrent-type cholesteatomas.Conclusion: 5-FU topical cream appeared effective for the treatment of cholesteatomas. (c) 2005 Elsevier Ireland Ltd. All rights reserved.