Impact of microbicides and sexually transmitted infections on mucosal immunity in the female genital tract
Impact of microbicides and sexually transmitted infections on mucosal immunity in the female genital tract
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DOI：
10.1111/j.1600-0897.2006.00436.x
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发表时间：
2006-11-01
影响因子：
3.6
通讯作者：
Herold, Betsy C.
中科院分区：
文献类型：
--
作者：
Keller, Marla J.;Herold, Betsy C.
人体免疫机能丧失病毒、生殖器疱疹和其他性传播感染是国家和全球卫生的一个重要优先事项，需要迅速发展安全有效的控制方法。局部杀微生物剂，自我管理的代理商设计的阴道使用，阻止在粘膜表面的传播可能提供一个现实的干预方法，可以在世界范围内分布。最佳的杀微生物剂应保护免受感染，但也必须是安全的，而不会对粘膜环境（包括宿主防御介质）产生不利影响。因此，杀微生物剂开发的一个关键组成部分是确定最佳的检测方法，可以作为替代标记物，以预测杀微生物剂的安全性，然后再进行大规模的临床试验。这将需要更好地了解女性生殖道粘膜免疫介质。
Human immunodeficiency virus, genital herpes, and other sexually transmitted infections are a critical national and global health priority requiring the rapid development of safe and effective control methods. Topical microbicides, self-administered agents designed for vaginal use, that block transmission at the mucosal surface may provide a realistic method of intervention that could be distributed worldwide. An optimal microbicide should protect against infection but must also be safe, without adversely affecting the mucosal environment, including mediators of host defense. Thus, a critical component in microbicides development is to identify optimal assays that could serve as surrogate markers to predict safety of microbicides prior to embarking on large-scale clinical trials. This will require a greater understanding of the mediators of mucosal immunity in the female genital tract.