Effects of short-term very low-calorie diet on intramyocellular lipid and insulin sensitivity in nondiabetic and type 2 diabetic subjects
Effects of short-term very low-calorie diet on intramyocellular lipid and insulin sensitivity in nondiabetic and type 2 diabetic subjects
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DOI：
10.1016/j.metabol.2007.05.008
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发表时间：
2008-01-01
影响因子：
9.8
通讯作者：
Garvey, W. Timothy
中科院分区：
文献类型：
--
作者：
Lara-Castro, Cristina;Newcomer, Bradley R.;Garvey, W. Timothy
该研究旨在分析短期极低热量饮食（VLCD）对一组肥胖非糖尿病和2型糖尿病受试者的细胞内脂质（IMCL）、全身脂肪和胰岛素敏感性的影响。7名未经治疗的2型糖尿病患者和5名肥胖的非糖尿病患者在VLCD治疗前后进行了为期6天的研究，使用质子磁共振波谱法量化IMCL，双能x线吸收仪评估体脂，高胰岛素-正血糖钳测量外周胰岛素敏感性。在两组中，总体脂量和体重指数的减少都很小，但具有统计学意义。相比之下，与基线值相比，饮食导致非糖尿病受试者（降低56%）和2型糖尿病受试者（降低40%）的IMCL显著降低(P
The study aimed to analyze the effects of a short-term very low-calorie diet (VLCD) on intramyocellular lipid (IMCL), total body fat, and insulin sensitivity in a group of obese nondiabetic and type 2 diabetic subjects. Seven untreated type 2 diabetic and 5 obese nondiabetic individuals were studied before and after a 6-day VLCD using proton magnetic resonance spectroscopy to quantify IMCL, dual-energy x-ray absorptiometry to assess body fat, and hyperinsulinemic-euglycemic clamps to measure peripheral insulin sensitivity. In both groups, decrements in total body fat mass and body mass index were small but statistically significant. In contrast, the diet resulted in a pronounced reduction in IMCL compared with baseline values in nondiabetic subjects (56% decrease) and type 2 diabetic subjects (40% decrease) (P