Dual time point 18F-fluorodeoxyglucose positron emission tomography/computed tomography fusion imaging (18F-FDG PET/CT) in primary breast cancer
Dual time point 18F-fluorodeoxyglucose positron emission tomography/computed tomography fusion imaging (18F-FDG PET/CT) in primary breast cancer
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DOI：
10.1186/s12885-019-6315-8
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发表时间：
2019-11-27
期刊：
影响因子：
3.8
通讯作者：
Tsuda, Hitoshi
中科院分区：
文献类型：
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作者：
Yamagishi, Yoji;Koiwai, Tomomi;Tsuda, Hitoshi
目的评价双时间点F-18-FDG PET/CT（F18-FDG PET/CT）检测乳腺癌60 min最大标准化摄取值（SUV（max）1）和120 min最大标准化摄取值（SUV（max）2）的百分比变化（Δ SUVmax%）的临床病理学意义和预后意义。方法对464例原发性乳腺癌患者行F-18-FDG PET/CT检查，术前进行分期。Δ SUV最大值%定义为（SUV（最大值）2 - SUV（最大值）1）/ SUV（最大值）1 x 100。通过受试者工作特征曲线（ROC）分析，探讨SUVmax参数（SUV（max）1和Delta SUVmax%）在复发事件中的最佳临界值。应用考克斯单因素和多因素分析SUV（max）1和Delta SUV max %的临床病理和预后意义。结果SUV（max）1和Delta SUV max %的最佳临界值分别为3.4和12.5。无复发生存（RFS）曲线在高SUV（max）1组和低SUV（max）1组之间（P = 0.0003）以及高Delta SUV max %组和低Delta SUV max %组之间（P = 0.0151）存在显著差异。在RFS的考克斯多变量分析中，SUV（max）1是一个独立的预后因素（P = 0.0267），但Delta SUV max %不是（P = 0.152）。SUV（max）1与Delta SUV max %之间存在弱相关性（P < 0.0001，R-2 = 0.166）。结合SUV（max）1和Delta SUVmax%，高SUV（max）1和高Delta SUVmax%亚组的RFS预后显著差于其他组（P = 0.0002）。结论双时间点F-18-FDG PET/CT显像可作为乳腺癌术后复发的预测指标。SUV（max）1和Delta SUV max %的组合能够比单独SUV（max）1更准确地识别预后较差的亚组。
Background To evaluate the clinicopathological and prognostic significance of the percentage change between maximum standardized uptake value (SUVmax) at 60 min (SUV(max)1) and SUVmax at 120 min (SUV(max)2) (Delta SUVmax%) using dual time point F-18-fluorodeoxyglucose emission tomography/computed tomography (F-18-FDG PET/CT) in breast cancer. Methods Four hundred and sixty-four patients with primary breast cancer underwent F-18-FDG PET/CT for preoperative staging. Delta SUVmax% was defined as (SUV(max)2 - SUV(max)1) / SUV(max)1 x 100. We explored the optimal cutoff value of SUVmax parameters (SUV(max)1 and Delta SUVmax%) referring to the event of relapse by using receiver operator characteristic curves. The clinicopathological and prognostic significances of the SUV(max)1 and Delta SUVmax% were analyzed by Cox's univariate and multivariate analyses. Results The optimal cutoff values of SUV(max)1 and Delta SUVmax% were 3.4 and 12.5, respectively. Relapse-free survival (RFS) curves were significantly different between high and low SUV(max)1 groups (P = 0.0003) and also between high and low Delta SUVmax% groups (P = 0.0151). In Cox multivariate analysis for RFS, SUV(max)1 was an independent prognostic factor (P = 0.0267) but Delta SUVmax% was not (P = 0.152). There was a weak correlation between SUV(max)1 and Delta SUVmax% (P < 0.0001, R-2 = 0.166). On combining SUV(max)1 and Delta SUVmax%, the subgroups of high SUV(max)1 and high Delta SUVmax% showed significantly worse prognosis than the other groups in terms of RFS (P = 0.0002). Conclusion Dual time point F-18-FDG PET/CT evaluation can be a useful method for predicting relapse in patients with breast cancer. The combination of SUV(max)1 and Delta SUVmax% was able to identify subgroups with worse prognosis more accurately than SUV(max)1 alone.