Scaling the microrheology of living cells
Scaling the microrheology of living cells
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DOI：
10.1103/physrevlett.87.148102
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发表时间：
2001-10-01
影响因子：
8.6
通讯作者：
Fredberg, JJ
中科院分区：
文献类型：
--
作者：
Fabry, B;Maksym, GN;Fredberg, JJ
我们报告了一个标度定律，它控制着各种活细胞类型在广泛的时间尺度和各种生物干预下的弹性和摩擦特性。这种比例将这些细胞识别为接近玻璃化转变的软玻璃材料，并暗示细胞骨架蛋白可能主要通过调节基质的有效噪声温度来调节细胞的机械性能。其实际含义是，有效噪声温度是细胞骨架变形、流动和重组能力的一个容易量化的量度。
We report a scaling law that governs both the elastic and frictional properties of a wide variety of living cell types, over a wide range of time scales and under a variety of biological interventions. This scaling identifies these cells as soft glassy materials existing close to a glass transition, and implies that cytoskeletal proteins may regulate cell mechanical properties mainly by modulating the effective noise temperature of the matrix. The practical implications are that the effective noise temperature is an easily quantified measure of the ability of the cytoskeleton to deform, flow, and reorganize.