Exercise ameliorates high-fat diet-induced metabolic and vascular dysfunction, and increases adipocyte progenitor cell population in brown adipose tissue
Exercise ameliorates high-fat diet-induced metabolic and vascular dysfunction, and increases adipocyte progenitor cell population in brown adipose tissue
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DOI：
10.1152/ajpregu.00806.2010
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发表时间：
2011-05-01
影响因子：
2.8
通讯作者：
Sun, Qinghua
中科院分区：
文献类型：
--
作者：
Xu, Xiaohua;Ying, Zhekang;Sun, Qinghua
Xu X，Ying Z，Cai M，Xu Z，Li Y，Jiang SY，Tzan K，Wang A，Parthasarathy S，He G，Rajagopalan S，Sun Q.运动可以改善高脂饮食引起的代谢和血管功能障碍，并增加棕色脂肪组织中的脂肪祖细胞数量。Am J Physiol Regul Integr Comp Physiol 300：R1115-R1125，2011。首次发表于2011年3月2日; doi：10.1152/ajpregu.00806.2010.-高脂饮食（HFD）与脂肪炎症有关，脂肪炎症导致代谢综合征的关键组成部分，包括肥胖和胰岛素抵抗。与肥胖相关的内脏脂肪组织质量增加是脂肪细胞增生和肥大的结果。为了研究运动对HFD诱导的代谢紊乱的影响，将雄性C57 BL/6小鼠分为四组：SED（久坐）-ND（正常饮食）、EX（运动）-ND、SED-HFD和EX-HFD。在电动跑步机上进行运动，15 m/min，40 min/d，5 d/wk，共8 wk。运动导致腹部脂肪含量和炎症的减少，葡萄糖耐量和胰岛素抵抗的改善，以及血管收缩和舒张反应的增强。与相同饮食的组相比，有或没有HFD的运动增加了棕色脂肪组织中假定的棕色脂肪细胞祖细胞，棕色和白色脂肪组织中棕色脂肪细胞特异性基因表达增加。运动训练促进棕色脂肪前体细胞向棕色脂肪细胞的分化，并促进解偶联蛋白1的表达。这些研究结果表明，运动改善高脂饮食诱导的代谢紊乱和血管功能障碍，并增加棕色脂肪组织中的脂肪祖细胞数量，从而有助于增强功能性棕色脂肪。
Xu X, Ying Z, Cai M, Xu Z, Li Y, Jiang SY, Tzan K, Wang A, Parthasarathy S, He G, Rajagopalan S, Sun Q. Exercise ameliorates high-fat diet-induced metabolic and vascular dysfunction, and increases adipocyte progenitor cell population in brown adipose tissue. Am J Physiol Regul Integr Comp Physiol 300: R1115-R1125, 2011. First published March 2, 2011; doi:10.1152/ajpregu.00806.2010.-A high-fat diet (HFD) is associated with adipose inflammation, which contributes to key components of metabolic syndrome, including obesity and insulin resistance. The increased visceral adipose tissue mass associated with obesity is the result of hyperplasia and hypertrophy of adipocytes. To investigate the effects of exercise on HFD-induced metabolic disorders, male C57BL/6 mice were divided into four groups: SED (sedentary)-ND (normal diet), EX (exercise)-ND, SED-HFD, and EX-HFD. Exercise was performed on a motorized treadmill at 15 m/min, 40 min/day, and 5 day/wk for 8 wk. Exercise resulted in a decrease in abdominal fat contents and inflammation, improvements in glucose tolerance and insulin resistance, and enhancement of vascular constriction and relaxation responses. Exercise with or without HFD increased putative brown adipocyte progenitor cells in brown adipose tissue compared with groups with the same diet, with an increase in brown adipocyte-specific gene expression in brown and white adipose tissue. Exercise training enhanced in vitro differentiation of the preadipocytes from brown adipose depots into brown adipocytes and enhanced the expression of uncoupling protein 1. These findings suggest that exercise ameliorates high-fat diet-induced metabolic disorders and vascular dysfunction, and increases adipose progenitor cell population in brown adipose tissue, which might thereby contribute to enhanced functional brown adipose.