Complete Genome Sequence of a Coxsackievirus B3 Isolated from a Sichuan Snub-Nosed Monkey
Complete Genome Sequence of a Coxsackievirus B3 Isolated from a Sichuan Snub-Nosed Monkey
复制标题
四川金丝猴柯萨奇病毒B3全基因组序列
DOI：
10.1128/jvi.02365-12
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发表时间：
2012-12-01
影响因子：
5.4
通讯作者：
Gao, Feng
中科院分区：
文献类型：
--
作者：
He, Wenqi;Lu, Huijun;Gao, Feng
柯萨奇病毒B3（Coxsackievirus B3，CVB 3）是小核糖核酸病毒科的一种肠道病毒，与心肌炎、无菌性脑膜炎和胰腺炎等疾病密切相关，对人类健康具有重要意义。除了人类，四川金丝猴也可能被CVB 3感染并致死。在这里，我们报告了第一个完整的基因组序列的一种新的柯萨奇病毒B3株，SSM-CVB 3，这是分离自死亡的四川金丝猴严重心肌炎。我们的研究结果可能有助于了解这种病毒的进化特征和分子发病机制。
ABSTRACT Coxsackievirus B3 (CVB3) is an enterovirus in the family Picornaviridae that is significant to human health, being associated with myocarditis, aseptic meningitis, and pancreatitis, among other conditions. In addition to humans, Sichuan snub-nosed monkeys can be infected and killed by CVB3. Here, we report the first complete genome sequence of a novel coxsackievirus B3 strain, SSM-CVB3, which was isolated from a deceased Sichuan snub-nosed monkey with severe myocarditis. Our findings may aid in understanding the evolutionary characteristics and molecular pathogenesis of this virus.