Hyperhomocysteinaemia; with reference to its neuroradiological aspects
Hyperhomocysteinaemia; with reference to its neuroradiological aspects
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DOI：
10.1007/bf00588024
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发表时间：
1995-07
期刊：
影响因子：
2.8
通讯作者：
M. Berg;M. Knaap;G. Boers;C. Stehouwer;J. Rauwerda;J. Valk
中科院分区：
文献类型：
--
作者：
M. Berg;M. Knaap;G. Boers;C. Stehouwer;J. Rauwerda;J. Valk
严重甚至轻微的高同型半胱氨酸血症可引起广泛的神经系统问题。近年来，其血管并发症，包括脑卒中，在儿童和年轻人中获得了特别的关注，因为高同型半胱氨酸血症是可治疗的，血管事件的复发是可以预防的。目前的知识导致高同型半胱氨酸血症的生化机制，血管病理和神经功能障碍的发病机制，以及脑损伤的各种模式进行了审查。本文讨论了MRI在高同型半胱氨酸血症诊断、随访和研究中的意义。
Severe or even mild hyperhomocysteinaemia can cause a wide range of neurological problems. In recent years its vascular complications, including cerebral stroke, in children and young adults have gained special interest, because hyperhomocysteinaemia is treatable and recurrence of vascular incidents may be preventable. Current knowledge about biochemical mechanisms leading to hyperhomocysteinaemia, the pathogenesis of vascular pathology and neurological disfunction, and the various patterns of cerebral damage are reviewed. The significance of MRI in diagnosis, follow-up and research on hyperhomocysteinaemia is discussed.