STIMULATION BY CENTRAL COMMAND OF LOCOMOTION, RESPIRATION AND CIRCULATION DURING EXERCISE
STIMULATION BY CENTRAL COMMAND OF LOCOMOTION, RESPIRATION AND CIRCULATION DURING EXERCISE
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DOI：
10.1016/0034-5687(85)90136-7
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发表时间：
1985-01-01
期刊：
影响因子：
--
通讯作者：
WALDROP, TG
中科院分区：
文献类型：
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作者：
ELDRIDGE, FL;MILLHORN, DE;WALDROP, TG
研究了19只在跑步机上正常行走或跑步的猫，以及16只在实际运动（即腿部运动神经的运动活动）中瘫痪的猫的运动（运动）与呼吸和循环反应之间的关系。制剂包括麻醉的完整脑猫和未麻醉的去皮层（下丘脑）和去脑（中脑）动物。除中脑猫外，其他各组均有自发的实际运动和有效运动。电刺激或注射GABA拮抗剂（微毒素）到下丘脑运动区引起运动的发展。在所有发生运动的病例中，尽管控制或消融呼吸反馈机制，呼吸和动脉压仍与运动活动水平成比例地增加。尽管没有肌肉收缩或肢体运动，代谢率也没有变化，但在有效运动期间，呼吸和动脉压也同样增加。该研究为运动过程中呼吸和循环比例变化的前馈或命令信号假说提供了实验支持。其操作不需要反馈机制。下丘脑发出的指令信号可能是运动中呼吸和循环变化的主要驱动。
The relationships between exercise (locomotion) and respiratory and circulatory responses in 19 cats that walked or ran normally on a treadmill, and in 16 paralyzed animals during fictive locomotion, i.e., locomotory activity in motor nerves to the legs [was studied]. Preparations included anesthetized cats with intact brains and unanesthetized decorticate (hypothalamic) and decerebrate (mesencephalic) animals. Spontaneous actual locomotion and fictive locomotion occurred in all preparations except the mesencephalic cats. Electrical stimulation or injection of a GABA antagonists (picrotoxin) into the hypothalamic locomotor region caused locomotion to develop. In all cases when locomotion occurred, respiration and arterial pressure increased in proportion to the level of locomotor activity despite control or ablation of respiratory feedback mechanisms. Respiration and arterial pressure increased similarly during fictive locomotion despite the absence of muscular contraction or limb movement and the lack of change of metabolic rate. The study provides experimental support for the feed-forward, or command signal, hypothesis for the genesis of proportional changes of respiration and circulation that occur during exercise. Feedback mechanisms are not required for its operation. Command signals emanating from the hypothalamus may provide the primary drive for changes of respiraton and circulation during exercise.