Regio-selective chlorination of vinca alkaloids catalyzed by Lewis acid
Regio-selective chlorination of vinca alkaloids catalyzed by Lewis acid
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DOI：
10.1007/s11426-011-4310-2
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发表时间：
2011-07-01
影响因子：
9.6
通讯作者：
Lin GuoQiang
中科院分区：
文献类型：
--
作者：
Fang LiSong;Zhang Qiao;Lin GuoQiang
在Lewis酸存在下，通过氯化反应，区域选择性地合成了新的C-17-氯代长春瑞滨或长春瑞滨衍生物。催化剂Cp2TiCl2在氯化反应中起着关键作用。
Novel C-17-chloro-substituted derivative of vinorelbine or vinflunine has been regio-selectively synthesized via the chlorination reaction in the presence of Lewis acid. The catalyst Cp2TiCl2 plays a key role in the chlorination reaction.