Sinonasal Glomangiopericytoma Case Report With Emphasis on the Differential Diagnosis
Sinonasal Glomangiopericytoma Case Report With Emphasis on the Differential Diagnosis
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DOI：
10.1043/2010-0233-cr.1
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发表时间：
2010-10-01
影响因子：
4.6
通讯作者：
McHugh, Jonathan B.
中科院分区：
文献类型：
--
作者：
Dandekar, Monisha;McHugh, Jonathan B.
血管球外皮细胞瘤（鼻窦型血管外皮细胞瘤）是一种罕见的鼻窦肿瘤，具有血管周围肌样表型。该肿瘤在位置、生物学行为和组织学特征上不同于传统的软组织血管外皮细胞瘤。提出的细胞起源是一个修改血管周围球样肌样细胞。血管球外皮细胞瘤是一种惰性肿瘤，好发于老年人的鼻窦，恶性潜能低，手术切除后预后良好。在组织学上，病变由弥漫性的、上皮下增殖的、均匀的、密集的梭形细胞组成，这些细胞以各种方式生长。通常存在由大小不等的血管通道组成的独特的血管网络，其中较小的血管显示血管周围玻璃样变。我们报告一位48岁女性鼻出血及鼻塞的病例，她被诊断为血管球外皮细胞瘤，并讨论组织学上的鉴别诊断。(Arch Pathol Lab Med. 2010;134：1444-1449）
Glomangiopericytoma (sinonasal-type hemangiopericytoma) is an uncommon sinonasal neoplasm with a perivascular myoid phenotype. This tumor differs from conventional soft tissue hemangiopericytoma in location, biologic behavior, and histologic features. The proposed cell of origin is a modified perivascular glomuslike myoid cell. Glomangiopericytoma is an indolent tumor that tends to arise in the sinonasal tract of older adults and has a low malignant potential with excellent prognosis after surgical resection. Histologically, this lesion is composed of a diffuse, subepithelial proliferation of bland, uniform, closely packed spindled cells growing in a variety of patterns. A distinctive vascular network composed of variably sized vascular channels, the smaller of which demonstrate perivascular hyalinization, is often present. We report the case of a 48-year-old woman with epistaxis and nasal obstruction who was diagnosed with glomangiopericytoma and discuss the histologic differential diagnosis. (Arch Pathol Lab Med. 2010;134:1444-1449)