Dapivirine-releasing vaginal rings produced by plastic freeforming additive manufacturing
Dapivirine-releasing vaginal rings produced by plastic freeforming additive manufacturing
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DOI：
10.1016/j.ijpharm.2019.118725
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发表时间：
2019-12-15
影响因子：
5.8
通讯作者：
Boyd, Peter
中科院分区：
文献类型：
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作者：
Welsh, Nicole R.;Malcolm, R. Karl;Boyd, Peter
在这里，我们报告了首次使用基于熔融热塑性塑料的高压材料喷射的增材制造（AM）技术来制造载达匹韦林（DPV）的阴道环（VR）。将VR与常规使用注射成型（IM）生产的VR进行比较。VR（外径54.0 mm，横截面直径4.0 mm）通过注塑成型或Arburg塑料自由成型（APF）-一种专有的液滴沉积成型（DDM）工艺，使用装载有10% w/w DPV的医用级热塑性聚氨酯（TPU）制造。这种独特的DDM工艺用于生产100%、50%和10%基质填充密度的环。与含有190-194 mg DPV的注塑成型环相比，具有10%密度（57-62 mg药物负载）的DDM印刷VR表现出高达7倍的DPV释放增加。这项工作表明，DDM使用的APF技术可用于制造不同的几何形状，密度和表面积的药物输送装置，以提供精确的药物释放动力学的控制水平。这项工作提供了一个新的机会，以增加水溶性差的化合物的释放或实现所需的剂量水平，使用较低的药物负载比那些需要使用传统的热塑性加工技术。
Here we report the first use of an additive manufacturing (AM) technique based on high pressure material jetting of molten thermoplastic for the fabrication of dapivirine (DPV) loaded vaginal rings (VRs). The VRs are compared to those produced conventionally using injection molding (IM). VRs (outer diameter 54.0 mm, cross-sectional diameter 4.0 mm) were manufactured by either injection molding or Arburg Plastic Freeforming (APF) - a proprietary droplet deposition modelling (DDM) process, using medical grade thermoplastic polyurethanes (TPUs) loaded with 10% w/w DPV. This unique DDM process was used to produce rings of 100, 50 and 10% matrix infill density. DDM printed VRs with 10% density (57-62 mg drug load) exhibited up to seven-fold increase in DPV release compared to injection molded rings containing 190-194 mg DPV. This work has shown that DDM using the APF technique can be used to manufacture drug delivery devices of varying geometries, densities and surface areas to give precise levels of control over the drug release kinetics. This work presents a new opportunity to increase the release of poorly water-soluble compounds or to achieve desired dosing levels using lower drug loadings than those required using conventional thermoplastic processing techniques.